Evidence map›Paper›PMID 38107545›Full record

ArticlePhysiological mini-reviews

INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions.

Ye Chen-Izu, Bence Hegyi, Zhong Jian, Balazs Horvath, John A Shaw, Tamas Banyasz, Leighton T Izu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Physiological mini-reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Ye Chen-IzuDepartment of Pharmacology, University of California, Davis, USA.
Bence HegyiDepartment of Pharmacology, University of California, Davis, USA.
Zhong JianDepartment of Pharmacology, University of California, Davis, USA.
Balazs HorvathDepartment of Pharmacology, University of California, Davis, USA.
John A ShawDepartment of Pharmacology, University of California, Davis, USA.
Tamas BanyaszDepartment of Pharmacology, University of California, Davis, USA.
Leighton T IzuDepartment of Pharmacology, University of California, Davis, USA.
University of California, Davis · US

Funding

Mechanical Load Effects on Cardiac Function and Heart DiseasesR35HL166575 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Ye Chen-Izu · 2023 to 2026
$4.4M
The Functional Connectome of the Mechanically Loaded CardiomyocyteR01HL149431 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE, IZU, LEIGHTON T. · 2020 to 2023
$2.7M
MECHANICAL LOAD EFFECT ON CARDIAC EXCITATION-CONTRACTION COUPLINGR01HL141460 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2019 to 2022
$2.6M
Novel Cell-in-Gel System for Mechanotransduction Study at the Single Cell LevelR01HL123526 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2015 to 2018
$1.8M
Decipher Mechano-Chemo-Transduction Pathway and Function in CardiomyocytesR01HL159993 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2021 to 2022
$1.5M
NHLBI NIH HHS R01 HL123526NHLBI NIH HHS R01 HL141460NHLBI NIH HHS R01 HL149431NHLBI NIH HHS R01 HL159993NHLBI NIH HHS R35 HL166575
6 · The paper itself

Abstract

Cardiac arrhythmias are associated with various forms of heart diseases. Ventricular arrhythmias present a significant risk for sudden cardiac death. Atrial fibrillations predispose to blood clots leading to stroke and heart attack. Scientists have been developing patch-clamp technology to study ion channels and action potentials (APs) underlying cardiac excitation and arrhythmias. Beyond the traditional patch-clamp techniques, innovative new techniques were developed for studying complex arrhythmia mechanisms. Here we review the recent development of methods including AP-Clamp, Dynamic Clamp, AP-Clamp Sequential Dissection, and Patch-Clamp-in-Gel. These methods provide powerful tools for researchers to decipher how the dynamic systems in excitation-Ca

Indexed as

action potentialarrhythmiacardiac myocyteelectrophysiologypatch-clamp

Identifiers

PMID38107545
PMCPMC10722976
OpenAlexW4389899931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.