Evidence map›Paper›PMID 38107466›Full record

ArticleCase reports in nephrology and dialysis

The Matter of Kidney Biopsy in Monoclonal Gammopathy of Renal Significance: A Case Report of a New Pattern of Immunoglobulin-Storing Histiocytosis.

Paolo Randone, Manuel Burdese, Antonella Barreca, Stefania Oliva, Enrico Sanna, Isabella Abbasciano, Patrizia Anania, Elena Boaglio, Luigi Biancone

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in nephrology and dialysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Paolo RandoneDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, "A. Vercellone," Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, Italy.
Manuel BurdeseDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, "A. Vercellone," Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, Italy.
Antonella BarrecaDivision of Pathology, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
Stefania OlivaMyeloma Unit, Division of Hematology, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
Enrico SannaDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, "A. Vercellone," Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, Italy.
Isabella AbbascianoDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, "A. Vercellone," Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, Italy.
Patrizia AnaniaDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, "A. Vercellone," Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, Italy.
Elena BoaglioDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, "A. Vercellone," Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, Italy.
Luigi BianconeDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, "A. Vercellone," Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, Italy.
University of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoclonal gammopathy of renal significance (MGRS) represents a group of disorders, characterized by paraproteinemia which causes renal damage. These disorders never meet the diagnostic criteria for multiple myeloma (MM) or lymphoproliferative disease. Crystal-storing histiocytosis is one of the rarest patterns of MGRS, characterized by an accumulation of light chains of crystals within histiocyte's cytoplasm, located in bone marrow or other extramedullary sites such as the kidney, cornea, or thyme. A very few cases have been described as immunoglobulin-storing histiocytosis (IgSH) without evidence of crystals. In the recent literature, only 3 cases of IgSH have been described so far, none renal. In all cases, these very peculiar histopathological patterns are associated with lymphoproliferative or plasma cellular disorders. Here, we report a very unusual IgSH pattern in a kidney biopsy, which led to prompt detection and early therapeutic intervention, in a patient with otherwise misdiagnosed MGRS.

Indexed as

Crystal-storing histiocytosisImmunoglobulin-storing histiocytosisMonoclonal gammopathy of renal significanceMultiple myeloma

Identifiers

PMID38107466
PMCPMC10723809
OpenAlexW4389775390

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.