Evidence map›Paper›PMID 38107175›Full record

ArticleRSC medicinal chemistry2023

Impact of multiple H/D replacements on the physicochemical properties of flurbiprofen.

Hiromasa Uchiyama, Kazuho Ban, Shiho Nozaki, Yui Ikeda, Takayoshi Ishimoto, Hiroyoshi Fujioka, Mako Kamiya, Ryugo Amari, Hirofumi Tsujino, Masayoshi Arai and 10 more

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hiromasa UchiyamaDepartment of Formulation Design and Pharmaceutical Technology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University 4-20-1 Nasahara Takatsuki Osaka 569-1094 Japan hiromasa.uchiyama@ompu.ac.jp.ORCID https://orcid.org/0000-0003-4752-6846
Kazuho BanGraduate School of Pharmaceutical Sciences, Osaka University 1-6, Yamada-oka Suita Osaka 565-0871 Japan sawama@phs.osaka-u.ac.jp.
Shiho NozakiGraduate School of Pharmaceutical Sciences, Osaka University 1-6, Yamada-oka Suita Osaka 565-0871 Japan sawama@phs.osaka-u.ac.jp.
Yui IkedaDepartment of Formulation Design and Pharmaceutical Technology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University 4-20-1 Nasahara Takatsuki Osaka 569-1094 Japan hiromasa.uchiyama@ompu.ac.jp.
Takayoshi IshimotoGraduate School of Advanced Science and Engineering, Hiroshima University 1-4-1 Kagamiyama Higashi-Hiroshima Hiroshima 739-8527 Japan.ORCID https://orcid.org/0000-0002-7423-5561
Hiroyoshi FujiokaDepartment of Life Science and Technology, Tokyo Institute of Technology 4259 Nagatsuta, Midori-ku Yokohama Kanagawa 226-8501 Japan.ORCID https://orcid.org/0000-0003-1904-0566
Mako KamiyaDepartment of Life Science and Technology, Tokyo Institute of Technology 4259 Nagatsuta, Midori-ku Yokohama Kanagawa 226-8501 Japan.
Ryugo AmariGraduate School of Pharmaceutical Sciences, Osaka University 1-6, Yamada-oka Suita Osaka 565-0871 Japan sawama@phs.osaka-u.ac.jp.
Hirofumi TsujinoGraduate School of Pharmaceutical Sciences, Osaka University 1-6, Yamada-oka Suita Osaka 565-0871 Japan sawama@phs.osaka-u.ac.jp.
Masayoshi AraiGraduate School of Pharmaceutical Sciences, Osaka University 1-6, Yamada-oka Suita Osaka 565-0871 Japan sawama@phs.osaka-u.ac.jp.
Sachi YamazoeFaculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts 97-1 Minamihokodate Koudo Kyotanabe, Kyoto 610-0395 Japan.
Keiko MaekawaFaculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts 97-1 Minamihokodate Koudo Kyotanabe, Kyoto 610-0395 Japan.ORCID https://orcid.org/0000-0003-4857-4137
Takuma KatoDepartment of Formulation Design and Pharmaceutical Technology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University 4-20-1 Nasahara Takatsuki Osaka 569-1094 Japan hiromasa.uchiyama@ompu.ac.jp.ORCID https://orcid.org/0000-0002-2561-8582
Mitsunobu DoiDepartment of Formulation Design and Pharmaceutical Technology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University 4-20-1 Nasahara Takatsuki Osaka 569-1094 Japan hiromasa.uchiyama@ompu.ac.jp.
Kazunori KadotaDepartment of Formulation Design and Pharmaceutical Technology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University 4-20-1 Nasahara Takatsuki Osaka 569-1094 Japan hiromasa.uchiyama@ompu.ac.jp.ORCID https://orcid.org/0000-0002-3370-6662
Yuichi TozukaDepartment of Formulation Design and Pharmaceutical Technology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University 4-20-1 Nasahara Takatsuki Osaka 569-1094 Japan hiromasa.uchiyama@ompu.ac.jp.
Naohito TomitaGifu Pharmaceutical University 1-25-4-Daigaku-nishi Gifu 501-1196 Japan.
Hironao SajikiGifu Pharmaceutical University 1-25-4-Daigaku-nishi Gifu 501-1196 Japan.ORCID https://orcid.org/0000-0003-2792-6826
Shuji AkaiGraduate School of Pharmaceutical Sciences, Osaka University 1-6, Yamada-oka Suita Osaka 565-0871 Japan sawama@phs.osaka-u.ac.jp.ORCID https://orcid.org/0000-0001-9149-8745
Yoshinari SawamaGraduate School of Pharmaceutical Sciences, Osaka University 1-6, Yamada-oka Suita Osaka 565-0871 Japan sawama@phs.osaka-u.ac.jp.ORCID https://orcid.org/0000-0002-9923-2412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although deuterium incorporation into pharmaceutical drugs is an attractive way to expand drug modalities, their physicochemical properties have not been sufficiently examined. This study focuses on examining the changes in physicochemical properties between flurbiprofen (FP) and flurbiprofen-

Identifiers

PMID38107175
PMCPMC10718516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.