Evidence map›Paper›PMID 38106971›Full record

ArticleFractal and fractional2022

Scale-Free Functional Brain Networks Exhibit Increased Connectivity, Are More Integrated and Less Segregated in Patients with Parkinson's Disease following Dopaminergic Treatment.

Orestis Stylianou, Zalan Kaposzta, Akos Czoch, Leon Stefanovski, Andriy Yabluchanskiy, Frigyes Samuel Racz, Petra Ritter, Andras Eke, Peter Mukli

Open access · goldAbstract read
In one paragraph

Article in Fractal and fractional, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Orestis StylianouDepartment of Physiology, Semmelweis University, 1094 Budapest, Hungary.ORCID 0000-0003-4457-4551
Zalan KaposztaDepartment of Physiology, Semmelweis University, 1094 Budapest, Hungary.
Akos CzochDepartment of Physiology, Semmelweis University, 1094 Budapest, Hungary.
Leon StefanovskiBerlin Institute of Health at Charité, University Hospital Berlin, Charitéplatz 1, 10117 Berlin, Germany.ORCID 0000-0003-0197-2576
Andriy YabluchanskiyVascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC, Oklahoma City, OK 73104, USA.
Frigyes Samuel RaczDepartment of Physiology, Semmelweis University, 1094 Budapest, Hungary.
Petra RitterBerlin Institute of Health at Charité, University Hospital Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Andras EkeDepartment of Physiology, Semmelweis University, 1094 Budapest, Hungary.
Peter MukliDepartment of Physiology, Semmelweis University, 1094 Budapest, Hungary.ORCID 0000-0003-4355-8103
Semmelweis University · HUHumboldt-Universität zu Berlin · DEUniversity of Oklahoma Health Sciences Center · US

Funding

Tracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI JUDITH A JAMES · 2013 to 2026
$68.2M
Visualizing insulin actions on neuronal metabolism and function using fluorescent biosensorsP20GM125528 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Veronica Galvan, William Edmund Sonntag · 2019 to 2026
$17.8M
GEROSCIENCE TRAINING PROGRAM IN OKLAHOMAT32AG052363 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Benjamin Francis Miller, William Edmund Sonntag · 2017 to 2026
$3.6M
Effects of NAD restoration on neurovascular coupling in community dwelling older adultsR01AG075834 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Aikaterini Thanou, Andriy Yabluchanskiy · 2022 to 2026
$3.2M
American Heart Association-American Stroke Association 966924BLRD VA I01 BX005592NIA NIH HHS R01 AG075834NIA NIH HHS T32 AG052363NIGMS NIH HHS P20 GM125528NIGMS NIH HHS U54 GM104938
6 · The paper itself

Abstract

Dopaminergic treatment (DT), the standard therapy for Parkinson's disease (PD), alters the dynamics of functional brain networks at specific time scales. Here, we explore the scale-free functional connectivity (FC) in the PD population and how it is affected by DT. We analyzed the electroencephalogram of: (i) 15 PD patients during DT (ON) and after DT washout (OFF) and (ii) 16 healthy control individuals (HC). We estimated FC using bivariate focus-based multifractal analysis, which evaluated the long-term memory

Indexed as

brain networkselectroencephalogramfunctional connectivitymultifractalParkinson’s disease

Identifiers

PMID38106971
PMCPMC10723163
OpenAlexW4311398669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.