ReviewCureus2023
Rats in Epilepsy Research: A Bibliometric Analysis of Citations Between 1969 and 2020 on Experimental Models in Epilepsy.
Review in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epilepsy stands as a prominent neurological disorder, affecting a substantial number of individuals who, unfortunately, do not respond to conventional antiepileptic medications. To unravel the intricate mechanisms underlying epileptic seizures and explore potential therapeutic avenues, researchers have turned to animal models. Among these models, rats have emerged as one of the cornerstones of epilepsy research. This bibliometric analysis embarks on the crucial task of delving into the role of rat models in deciphering the mysteries of epileptic seizures and, notably, pinpointing the most prevalent models in use. Our study harnessed Scopus' citation tracking feature to review a range of research papers dating from 1969 to 2020, all dedicated to the exploration of epileptic seizures in rats. The citations that emerged from this rigorous process were subjected to thematic coding, primarily centered around the specific epileptic animal models employed, and subsequently, comprehensive descriptive statistics were computed. In this effort, we found a total of 1,318 publications that explore the world of rat studies, accumulating a substantial citation count of 44,824 references. This analysis illuminated the invaluable role that research employing rat models has played in shaping our current clinical understanding of epileptic seizures. Notably, several models have emerged as predominant forces in this field, including those induced by pilocarpine, pentylenetetrazole (PTZ), kainic acid (KA), electric kindling, and electroshock. This bibliometric exploration serves as a resounding reminder of the pivotal position that rat models occupy in advancing our comprehension of epilepsy. These findings resonate strongly, underscoring the continued importance of directing research and development funding toward this debilitating disorder, with the ultimate aim of maximizing the benefits for the patients grappling with this condition. The potential to revolutionize our approach to epilepsy and enhance the quality of life for those affected remains a beacon of hope, illuminated by the contributions of these tireless researchers and their trusty rat companions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.