ArticleKidney international reports2023
Podocyte Infolding Glomerulopathy: A Special Morphology of Podocyte Injury Caused by Heterogeneous Diseases.
Article in Kidney international reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 10 citations in OpenAlex.
- Morphological subtypes and clinicopathological features of podocyte infolding glomerulopathy: retrospective nationwide Japanese cohort study of 93 cases.Clinical and experimental nephrology · 2026Article
- Histopathological Examination of Clustering Microspheres and Podocyte Infolding in the Glomerular Basement Membrane Using Low-vacuum Scanning Electron Microscopy.Internal medicine (Tokyo, Japan) · 2026Article
- Podocyte infolding glomerulopathy in a Japanese girl with systemic lupus erythematosus.CEN case reports · 2026Article
- Podocyte infolding glomerulopathy in a school-aged child.Pediatric nephrology (Berlin, Germany) · 2025Article
- Genotype-Based Molecular Mechanisms in Alport Syndrome.Journal of the American Society of Nephrology : JASN · 2025Review
- Laser capture microdissection.Nature reviews. Methods primers · 2025Article
- Diagnosis of Glomerular Disease With Podocyte Infolding, Microspherical, and Microtubular Glomerular Basement Membrane Inclusions.Kidney international reports · 2023Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Podocyte infolding glomerulopathy (PIG) is a newly recognized rare glomerular injury. The clinical significance and mechanism of this injury pattern remains unclear. Methods: We conducted a retrospective study of renal biopsies from January 2018 to December 2020 in Kingmed Diagnostics. The renal biopsy features and clinical data were reviewed. Laser scanning microdissection and mass spectrometry (LMD/MS) was conducted to analyze the potential mechanism. Results: A total of 116 (0.092%) out of 126,086 biopsies were diagnosed as PIG during the period. Of these, 89 (76.7%) cases were found to have PIG coexisting with immune-complex associated glomerulonephritis (IC-PIG) whereas 27 (23.3%) were identified as isolated PIG without immunoglobulin or complement deposition. Systemic lupus erythematosus (SLE), especially with membranous lupus nephritis (LN), was diagnosed in most (70.8%) IC-PIG cases. Of the isolated PIG cases, 51.9% had no known underlying conditions; however, a relatively high positive rate (42.1%) of antinuclear antibody (ANA) was detected. Nearly half (47.5%) of the patients presented with nephrotic syndrome (NS). PIG grade was associated with proteinuria in isolated PIG ( Conclusion: PIG is a rare podocyte injury that can exist alone without underlying disease or be concurrent with various diseases, especially SLE. Podocyte cytoskeletal protein ACTN4 and tubulin beta-4 chain were dysregulated, which may be involved in the mechanism of PIG.
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