Evidence map›Paper›PMID 38106199›Full record

ArticlebioRxiv : the preprint server for biology2023

Cell type-specific loops linked to RNA polymerase II elongation in human neural differentiation.

Katelyn R Titus, Zoltan Simandi, Harshini Chandrashekar, Dominik Paquet, Jennifer E Phillips-Cremins

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Katelyn R TitusDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-8594-729X
Zoltan SimandiDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-8894-1259
Harshini ChandrashekarDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-5424-2791
Dominik PaquetInstitute for Stroke and Dementia Research, Ludwig Maximilians Universitat, Munich, Germany.ORCID 0000-0003-2065-1639
Jennifer E Phillips-CreminsDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-4702-0450
University of Pennsylvania · USLudwig-Maximilians-Universität München · DE

Funding

From 3D genomes to neural connectomes: Higher-order chromatin mechanisms encoding long-term memoryDP1MH129957 · NIMH · WASHINGTON UNIVERSITY · PI PHILLIPS-CREMINS, JENNIFER ELIZABETH · 2021 to 2025
$5.7M
Engineering and Imaging 3D genome structure-function dynamics across time scalesU01DK127405 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BLOBEL, GERD A, PHILLIPS-CREMINS, JENNIFER ELIZABETH · 2020 to 2024
$5.7M
Elucidating the 3-D epigenetic determinants of activity-dependent gene expression in mammalian neuronsR01NS114226 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI PHILLIPS-CREMINS, JENNIFER ELIZABETH, SHEPHERD, JASON D · 2020 to 2024
$2.3M
NIDDK NIH HHS U01 DK127405NIMH NIH HHS DP1 MH129957NINDS NIH HHS R01 NS114226
6 · The paper itself

Abstract

DNA is folded into higher-order structures that shape and are shaped by genome function. The role for long-range loops in the establishment of new gene expression patterns during cell fate transitions remains poorly understood. Here, we investigate the link between cell-specific loops and RNA polymerase II (RNAPolII) during neural lineage commitment. We find thousands of loops decommissioned or gained

Identifiers

PMID38106199
PMCPMC10723365
OpenAlexW4389356308

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.