Evidence map›Paper›PMID 38106197›Full record

ArticlebioRxiv : the preprint server for biology2023

Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents.

Naima S Dahir, Yijun Gui, Yanan Wu, Patrick R Sweeney, Savannah Y Williams, Luis E Gimenez, Tomi K Sawyer, Stephen T Joy, Anna K Mapp, Roger D Cone

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Naima S DahirLife Sciences Institute, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-9963-8738
Yijun GuiLife Sciences Institute, University of Michigan, Ann Arbor, MI.
Yanan WuLife Sciences Institute, University of Michigan, Ann Arbor, MI.
Patrick R SweeneyDepartment of Molecular and Integrative Physiology, University of Illinois, Urbana-Champaign, IL.ORCID 0009-0009-8638-8926
Savannah Y WilliamsLife Sciences Institute, University of Michigan, Ann Arbor, MI.
Luis E GimenezLife Sciences Institute, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-0110-2135
Tomi K SawyerCourage Therapeutics, 64 Homer Street, Newton, Massachusetts 02459, United States.
Stephen T JoyLife Sciences Institute, University of Michigan, Ann Arbor, MI.
Anna K MappLife Sciences Institute, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-0791-8327
Roger D ConeLife Sciences Institute, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-3333-5651
University of Michigan · USUniversity of Illinois Urbana-Champaign · US

Funding

Multidisciplinary Training Program in Basic Diabetes ResearchT32DK101357 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETER ARVAN, Ormond A MacDougald · 2014 to 2026
$4.1M
Sexually Dimorphic Expression and Function of the Melanocortin-3 ReceptorR01DK126715 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CONE, ROGER D. · 2020 to 2022
$1.0M
MC3R inhibition as a strategy to maintain weight loss in obesityR00DK127065 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SWEENEY, PATRICK · 2022 to 2024
$737k
NIDDK NIH HHS R00 DK127065NIDDK NIH HHS R01 DK126715NIDDK NIH HHS T32 DK101357
6 · The paper itself

Abstract

The melanocortin-3 receptor (MC3R) acts presynaptically to regulate GABA release from agouti-related protein (AgRP) nerve terminals and thus may be a negative regulator of multiple circuits involved in feeding behavior and energy homeostasis. Here, we examined the role of MC3R in regulating the response to various anorexigenic agents. Our findings reveal that genetic deletion or pharmacological inhibition of MC3R improves the dose responsiveness to Glucagon-like peptide 1 (GLP1) agonists, as assayed by inhibition of food intake and weight loss. An enhanced anorectic response to other agents, including the acute satiety factors peptide YY (PYY

Identifiers

PMID38106197
PMCPMC10723368
OpenAlexW4389462110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.