Evidence map›Paper›PMID 38106196›Full record

ArticlebioRxiv : the preprint server for biology2023

An IL-2 mutein increases IL-10 and CTLA-4-dependent suppression of dendritic cells by regulatory T cells.

Braxton L Jamison, Matthew Lawrance, Chun Jing Wang, Hannah A DeBerg, David M Sansom, Marc A Gavin, Lucy S K Walker, Daniel J Campbell

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Braxton L JamisonCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, WA.
Matthew LawranceSystems Immunology, Benaroya Research Institute, Seattle, WA.
Chun Jing WangInstitute of Immunity & Transplantation, Pears Building, University College London Division of Infection & Immunity, London, UK.
Hannah A DeBergSystems Immunology, Benaroya Research Institute, Seattle, WA.
David M SansomInstitute of Immunity & Transplantation, Pears Building, University College London Division of Infection & Immunity, London, UK.
Marc A GavinInduPro, Seattle, WA.
Lucy S K WalkerInstitute of Immunity & Transplantation, Pears Building, University College London Division of Infection & Immunity, London, UK.
Daniel J CampbellCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, WA.ORCID 0000-0002-9652-7178
Benaroya Research InstituteUniversity College London · GBUniversity of Washington · US

Funding

Mechanisms of autoimmune disease risk in IL2/IL2RA-dependent immune toleranceR01AI154773 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI CAMPBELL, DANIEL J, WELLS, ANDREW D · 2021 to 2025
$3.8M
Targeting the IL-2/regulatory T cell axis for autoimmune disease prevention in realistic animal modelsR01AI136475 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI CAMPBELL, DANIEL J, ZIEGLER, STEVEN F · 2018 to 2022
$3.4M
Mechanisms of Il-2-mediated immune toleranceR21AI172140 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI CAMPBELL, DANIEL J · 2023 to 2024
$477k
NIAID NIH HHS R01 AI136475NIAID NIH HHS R01 AI154773NIAID NIH HHS R21 AI172140
6 · The paper itself

Abstract

Interleukin-2 (IL-2) variants with increased CD25 dependence that selectively expand Foxp3

Identifiers

PMID38106196
PMCPMC10723345
OpenAlexW4389303747

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.