Evidence map›Paper›PMID 38106172›Full record

ArticlebioRxiv : the preprint server for biology2023

A niche-derived non-ribosomal peptide triggers planarian sexual development.

Melanie Issigonis, Katherine L Browder, Rui Chen, James J Collins, Phillip A Newmark

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Melanie IssigonisMorgridge Institute for Research, University of Wisconsin-Madison; Madison, WI 53715.ORCID 0000-0002-2818-8389
Katherine L BrowderDepartment of Integrative Biology, University of Wisconsin-Madison; Madison, WI 53715.
Rui ChenDepartment of Pharmacology, UT Southwestern Medical Center; Dallas, TX 75390.
James J CollinsDepartment of Pharmacology, UT Southwestern Medical Center; Dallas, TX 75390.
Phillip A NewmarkMorgridge Institute for Research, University of Wisconsin-Madison; Madison, WI 53715.ORCID 0000-0003-0793-022X
Howard Hughes Medical Institute · USSouthwestern Medical Center · USUniversity of Wisconsin–Madison · US

Funding

Stem cell proliferation and differentiation in planariaR01HD043403 · NICHD · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Phillip A Newmark · 2003 to 2026
$5.1M
Characterizing sexual development of the human parasite Schistosoma mansoniR01AI150776 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI COLLINS, JAMES J · 2020 to 2024
$2.7M
NIAID NIH HHS R01 AI150776NICHD NIH HHS R01 HD043403
6 · The paper itself

Abstract

Germ cells are regulated by local microenvironments (niches), which secrete instructive cues. Conserved developmental signaling molecules act as niche-derived regulatory factors, yet other types of niche signals remain to be identified. Single-cell RNA-sequencing of sexual planarians revealed niche cells expressing a non-ribosomal peptide synthetase (

Indexed as

germ cellmonoamineregenerationSchmidtea mediterraneastem cell niche

Identifiers

PMID38106172
PMCPMC10723454
OpenAlexW4389442825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.