Evidence map›Paper›PMID 38106166›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology.

Saashi A Bedford, Meng-Chuan Lai, Michael V Lombardo, Bhismadev Chakrabarti, Amber Ruigrok, John Suckling, Evdokia Anagnostou, Jason P Lerch, Margot Taylor, Rob Nicolson and 17 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Saashi A BedfordAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK.
Meng-Chuan LaiAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK.
Michael V LombardoLaboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy.
Bhismadev ChakrabartiAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK.
Amber RuigrokAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK.
John SucklingBrain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK.
Evdokia AnagnostouBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
Jason P LerchProgram in Neurosciences and Mental Health, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Margot TaylorProgram in Neurosciences and Mental Health, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Rob NicolsonDepartment of Psychiatry, University of Western Ontario, London, Ontario, Canada.
Georgiades SteliosMcMaster University, Hamilton, Ontario, Canada.
Jennifer CrosbieDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5T 1R8, Canada.
Russell SchacharDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5T 1R8, Canada.
Elizabeth KelleyDepartment of Psychology, Queen's University, Kingston, ON K7L 3N6 Canada.
Jessica JonesDepartment of Psychology, Queen's University, Kingston, ON K7L 3N6 Canada.
Paul D ArnoldThe Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Eric CourchesneDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Karen PierceDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Lisa T EylerDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Kathleen CampbellDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Cynthia Carter BarnesDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Jakob SeidlitzDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Aaron F Alexander-BlochDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Edward T BullmoreBrain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK.
Simon Baron-CohenAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK.
Richard A I BethlehemAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK.
MRC AIMS Consortium and Lifespan Brain Chart Consortium

Funding

Detection of ASD at the 1st birthday as standard of care: The Get SET Early ModelR01MH104446 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIERCE, KAREN L · 2014 to 2018
$6.0M
Discovering Neural Biomarkers of Language and Social Development in ASD ToddlersR01DC016385 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COURCHESNE, ERIC, PIERCE, KAREN L · 2017 to 2021
$3.0M
NIDCD NIH HHS R01 DC016385NIMH NIH HHS R01 MH104446Wellcome Trust
6 · The paper itself

Abstract

Background: Autism and attention deficit hyperactivity disorder (ADHD) are heterogeneous neurodevelopmental conditions with complex underlying neurobiology. Despite overlapping presentation and sex-biased prevalence, autism and ADHD are rarely studied together, and sex differences are often overlooked. Normative modelling provides a unified framework for studying age-specific and sex-specific divergences in neurodivergent brain development. Methods: Here we use normative modelling and a large, multi-site neuroimaging dataset to characterise cortical anatomy associated with autism and ADHD, benchmarked against models of typical brain development based on a sample of over 75,000 individuals. We also examined sex and age differences, relationship with autistic traits, and explored the co-occurrence of autism and ADHD (autism+ADHD). Results: We observed robust neuroanatomical signatures of both autism and ADHD. Overall, autistic individuals showed greater cortical thickness and volume localised to the superior temporal cortex, whereas individuals with ADHD showed more global effects of cortical thickness increases but lower cortical volume and surface area across much of the cortex. The autism+ADHD group displayed a unique pattern of widespread increases in cortical thickness, and certain decreases in surface area. We also found evidence that sex modulates the neuroanatomy of autism but not ADHD, and an age-by-diagnosis interaction for ADHD only. Conclusions: These results indicate distinct cortical differences in autism and ADHD that are differentially impacted by age, sex, and potentially unique patterns related to their co-occurrence.

Identifiers

PMID38106166
PMCPMC10723556

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.