Evidence map›Paper›PMID 38106152›Full record

ArticlebioRxiv : the preprint server for biology2023

RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4.

Hannah N W Weinstein, Kevin Hu, Lisa Fish, Yih-An Chen, Paul Allegakoen, Keliana S F Hui, Julia H Pham, Maria B Baco, Hanbing Song, Andrew O Giacomelli and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Hannah N W WeinsteinDivision of Hematology/Oncology, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Bakar Computational Health Sciences Institute, Institute for Human Genetics, University of California; San Francisco, USA.ORCID 0000-0001-8409-4654
Kevin HuDivision of Hematology/Oncology, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Bakar Computational Health Sciences Institute, Institute for Human Genetics, University of California; San Francisco, USA.ORCID 0000-0002-3631-8294
Lisa FishDepartment of Biochemistry and Biophysics, University of California; San Francisco, USA.
Yih-An ChenDivision of Hematology/Oncology, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Bakar Computational Health Sciences Institute, Institute for Human Genetics, University of California; San Francisco, USA.
Paul AllegakoenDivision of Hematology/Oncology, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Bakar Computational Health Sciences Institute, Institute for Human Genetics, University of California; San Francisco, USA.
Keliana S F HuiDivision of Hematology/Oncology, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Bakar Computational Health Sciences Institute, Institute for Human Genetics, University of California; San Francisco, USA.
Julia H PhamDivision of Hematology/Oncology, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Bakar Computational Health Sciences Institute, Institute for Human Genetics, University of California; San Francisco, USA.
Maria B BacoBroad Institute of MIT and Harvard; Cambridge, USA.
Hanbing SongDivision of Hematology/Oncology, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Bakar Computational Health Sciences Institute, Institute for Human Genetics, University of California; San Francisco, USA.ORCID 0000-0002-2164-8813
Andrew O GiacomelliTumor Immunotherapy Program, Princess Margaret Cancer Center; Toronto, Canada.
Francisca VazquezBroad Institute of MIT and Harvard; Cambridge, USA.
Mahmoud GhandiBroad Institute of MIT and Harvard; Cambridge, USA.
Hani GoodarziDepartment of Biochemistry and Biophysics, University of California; San Francisco, USA.ORCID 0000-0002-9648-8949
Franklin W HuangDivision of Hematology/Oncology, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Bakar Computational Health Sciences Institute, Institute for Human Genetics, University of California; San Francisco, USA.
UCSF Helen Diller Family Comprehensive Cancer Center · USBroad Institute · USUniversity of California, San Francisco · USPrincess Margaret Cancer Centre · CA

Funding

The RNA structural code underlying pathological regulation of RNA splicing in metastasisR01CA244634 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOODARZI, HANI · 2021 to 2025
$1.8M
NCI NIH HHS R01 CA244634
6 · The paper itself

Abstract

Microsatellite instability high (MSI-H) tumors are malignant tumors that, despite harboring a high mutational burden, often have intact

Identifiers

PMID38106152
PMCPMC10723389
OpenAlexW4389559806

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.