Evidence map›Paper›PMID 38106148›Full record

ArticlebioRxiv : the preprint server for biology2023

Electrochemical DNA-based sensors for measuring cell-generated forces.

Mahmoud Amouzadeh Tabrizi, Priyanka Bhattacharyya, Ru Zheng, Mingxu You

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mahmoud Amouzadeh TabriziDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
Priyanka BhattacharyyaDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
Ru ZhengDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
Mingxu YouDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.ORCID 0000-0003-3293-9760
University of Massachusetts Amherst · US

Funding

Chemistry-Biology Interface Predoctoral Training GrantT32GM139789 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ERIC Robert STRIETER · 2021 to 2026
$3.4M
Defining Mechanical Landscapes at Cell-Cell JunctionsR35GM133507 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Mingxu You · 2019 to 2026
$2.8M
NIGMS NIH HHS R35 GM133507NIGMS NIH HHS T32 GM139789
6 · The paper itself

Abstract

Mechanical forces play an important role in cellular communication and signaling. We developed in this study novel electrochemical DNA-based force sensors for measuring cell-generated adhesion forces. Two types of DNA probes, i.e., tension gauge tether and DNA hairpin, were constructed on the surface of a smartphone-based electrochemical device to detect piconewton-scale cellular forces at tunable levels. Upon experiencing cellular tension, the unfolding of DNA probes induces the separation of redox reporters from the surface of the electrode, which results in detectable electrochemical signals. Using integrin-mediated cell adhesion as an example, our results indicated that these electrochemical sensors can be used for highly sensitive, robust, simple, and portable measurement of cell-generated forces.

Identifiers

PMID38106148
PMCPMC10723317
OpenAlexW4389332081

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.