Evidence map›Paper›PMID 38106104›Full record

ArticlebioRxiv : the preprint server for biology2023

Permanent deconstruction of intracellular primary cilia in differentiating granule cell neurons.

Carolyn M Ott, Sandii Constable, Tri M Nguyen, Kevin White, Wei-Chung Allen Lee, Jennifer Lippincott-Schwartz, Saikat Mukhopadhyay

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Carolyn M OttJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.ORCID 0000-0001-5246-1229
Sandii ConstableDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-3809-4976
Tri M NguyenDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9936-1794
Kevin WhiteDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Wei-Chung Allen LeeDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4618-295X
Jennifer Lippincott-SchwartzJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.ORCID 0000-0002-8601-3501
Saikat MukhopadhyayDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-4790-3090
The University of Texas Southwestern Medical Center · USHoward Hughes Medical Institute · USBoston Children's Hospital · USHarvard University · US

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
Signaling at the primary cilium in development and diseaseR35GM144136 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Saikat Mukhopadhyay · 2022 to 2026
$1.6M
Cerebellar network mapping with a high-throughput TEM platformRF1MH114047 · NIMH · HARVARD MEDICAL SCHOOL · PI LEE, WEI-CHUNG ALLEN · 2017 to 2017
$1.3M
Spinning Disk Confocal for UT SouthwesternS10OD028630 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2020 to 2020
$600k
Novel EM technologies for imaging neural network anatomyR21NS085320 · NINDS · HARVARD MEDICAL SCHOOL · PI LEE, WEI-CHUNG ALLEN · 2013 to 2014
$430k
NCI NIH HHS P30 CA142543NIGMS NIH HHS R35 GM144136NIH HHS S10 OD028630NIMH NIH HHS RF1 MH114047NINDS NIH HHS R21 NS085320
6 · The paper itself

Abstract

Primary cilia on granule cell neuron progenitors in the developing cerebellum detect sonic hedgehog to facilitate proliferation. Following differentiation, cerebellar granule cells become the most abundant neuronal cell type in the brain. While essential during early developmental stages, the fate of granule cell cilia is unknown. Here, we provide nanoscopic resolution of ciliary dynamics

Indexed as

centrosomecerebellumCiliaelectron microscopygranule cellhedgehogmedulloblastomamother centriole

Identifiers

PMID38106104
PMCPMC10723395
OpenAlexW4389521582

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.