Evidence map›Paper›PMID 38106101›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Mitochondrial DNA Copy Number Variation in Asthma Risk, Severity, and Exacerbations.

Weiling Xu, Yun Soo Hong, Bo Hu, Suzy A A Comhair, Allison J Janocha, Joe G Zein, Ruoying Chen, Deborah A Meyers, David T Mauger, Victor E Ortega and 14 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 14 institutions in 1 country.

Weiling XuDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Yun Soo HongMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Bo HuDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Suzy A A ComhairDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Allison J JanochaDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Joe G ZeinRespiratory Institute, Cleveland Clinic, Cleveland, Ohio.
Ruoying ChenDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Deborah A MeyersDepartment of Medicine, University of Arizona, Tucson, Arizona.
David T MaugerDepartment of Public Health Sciences, Pennsylvania State University School of Medicine, Hershey, Pennsylvania.
Victor E OrtegaDepartment of Internal Medicine, Division of Respiratory Medicine, Mayo Clinic, Scottsdale, Arizona.
Eugene R BleeckerDepartment of Medicine, University of Arizona, Tucson, Arizona.
Mario CastroDepartment of Medicine, University of Kansas School of Medicine, Kansas City, Kansas.
Loren C DenlingerDivision of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin, Madison, Wisconsin.
John V FahyDepartment of Medicine, San Francisco School of Medicine, University of California, San Francisco, California.
Elliot IsraelDepartment of Medicine, Harvard Medical School, Boston, Massachusetts.
Bruce D LevyDepartment of Medicine, Harvard Medical School, Boston, Massachusetts.
Nizar N JarjourDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Wendy C MooreDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Sally E WenzelDepartment of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Benjamin GastonWells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana.
Chunyu LiuDepartment of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts.
Dan E ArkingMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Serpil C ErzurumDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
National Heart, Lung, and Blood Institute (NHLBI) Severe Asthma Research Program (SARP) and TOPMed mtDNA Working Group in NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Cleveland Clinic · USCerner (United States) · USHarvard University · USJohns Hopkins University · USUniversity of Arizona · USUniversity of Wisconsin–Madison · USBoston University · USIndiana University School of MedicineMayo Clinic in Arizona · USPennsylvania State University · USUniversity of California, San Francisco · USUniversity of Kansas · USUniversity of Pittsburgh · USWake Forest University · US

Funding

Targeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI REIZES, OFER · 2011 to 2020
$26.8M
Tissue Processing and Cell Culture COreP01HL081064 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ARONICA, MARK A · 2006 to 2019
$17.8M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Clinical Coordinating Center for the Severe Asthma Research Program (SARP)U10HL109086 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MAUGER, DAVID T. · 2011 to 2017
$8.1M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
AMSA: ALXR/FBR Mediated Signaling in Severe AsthmaU10HL109172 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, LEVY, BRUCE D · 2011 to 2016
$4.2M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
Clinical and Molecular Phenotypes of Severe AsthmaU10HL109146 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2011 to 2016
$4.0M
Implications and Stability of Clinical and Molecular Phenotypes of Severe AsthmaU10HL109152 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WENZEL, SALLY E · 2011 to 2016
$3.9M
Stability of Severe Asthma Phenotypes: Impact of ExacerbationsU10HL109168 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2011 to 2016
$3.9M
Severe Asthma Research Program (SARP)-Washington UniversityU10HL109257 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 2011 to 2016
$3.8M
NHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS P01 HL081064NHLBI NIH HHS P01 HL103453NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL144569NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U10 HL109086NHLBI NIH HHS U10 HL109146NHLBI NIH HHS U10 HL109152NHLBI NIH HHS U10 HL109164NHLBI NIH HHS U10 HL109168NHLBI NIH HHS U10 HL109172NHLBI NIH HHS U10 HL109250NHLBI NIH HHS U10 HL109257
6 · The paper itself

Abstract

Rationale: Although airway oxidative stress and inflammation are central to asthma pathogenesis, there is limited knowledge of the relationship of asthma risk, severity, or exacerbations to mitochondrial dysfunction, which is pivotal to oxidant generation and inflammation. Objectives: We investigated whether mitochondrial DNA copy number (mtDNA-CN) as a measure of mitochondrial function is associated with asthma diagnosis, severity, oxidative stress, and exacerbations. Methods: We measured mtDNA-CN in blood in two cohorts. In the UK Biobank (UKB), we compared mtDNA-CN in mild and moderate-severe asthmatics to non-asthmatics. In the Severe Asthma Research Program (SARP), we evaluated mtDNA-CN in relation to asthma severity, biomarkers of oxidative stress and inflammation, and exacerbations. Measures and Main Results: In UK Biobank, asthmatics ( Conclusions: Asthma is characterized by mitochondrial dysfunction. Higher mtDNA-CN identifies an exacerbation-resistant asthma phenotype, suggesting mitochondrial function is important in exacerbation risk.

Indexed as

AsthmaExacerbationsMitochondrial DNA

Identifiers

PMID38106101
PMCPMC10723502
OpenAlexW4389428159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.