Evidence map›Paper›PMID 38106086›Full record

ArticlebioRxiv : the preprint server for biology2023

AKAP150-anchored PKA regulation of synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the lateral habenula.

S C Simmons, W J Flerlage, L D Langlois, R D Shepard, C Bouslog, E H Thomas, K M Gouty, J L Sanderson, S Gouty, B M Cox and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

S C SimmonsUniformed Services University of the Health Sciences, Department of Pharmacology, Bethesda, Maryland 20814, USA.
W J FlerlageUniformed Services University of the Health Sciences, Department of Pharmacology, Bethesda, Maryland 20814, USA.
L D LangloisUniformed Services University of the Health Sciences, Department of Pharmacology, Bethesda, Maryland 20814, USA.
R D ShepardUniformed Services University of the Health Sciences, Department of Pharmacology, Bethesda, Maryland 20814, USA.
C BouslogUniformed Services University of the Health Sciences, Department of Pharmacology, Bethesda, Maryland 20814, USA.
E H ThomasUniformed Services University of the Health Sciences, Department of Pharmacology, Bethesda, Maryland 20814, USA.
K M GoutyUniformed Services University of the Health Sciences, Department of Pharmacology, Bethesda, Maryland 20814, USA.
J L SandersonDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
S GoutyUniformed Services University of the Health Sciences, Department of Pharmacology, Bethesda, Maryland 20814, USA.
B M CoxUniformed Services University of the Health Sciences, Department of Pharmacology, Bethesda, Maryland 20814, USA.
M L Dell'AcquaDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
F S NugentUniformed Services University of the Health Sciences, Department of Pharmacology, Bethesda, Maryland 20814, USA.ORCID 0000-0002-8840-6923
Uniformed Services University of the Health Sciences · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Intrinsic CRF signaling within the lateral habenulaR21MH132136 · NIMH · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI NUGENT, FERESHTEH S · 2023 to 2024
$418k
NIMH NIH HHS R21 MH132136
6 · The paper itself

Abstract

Numerous studies of hippocampal synaptic function in learning and memory have established the functional significance of the scaffolding A-kinase anchoring protein 150 (AKAP150) in kinase and phosphatase regulation of synaptic receptor and ion channel trafficking/function and hence synaptic transmission/plasticity, and neuronal excitability. Emerging evidence also suggests that AKAP150 signaling may play a critical role in brain's processing of rewarding/aversive experiences. Here we focused on an unexplored role of AKAP150 in the lateral habenula (LHb), a diencephalic brain region that integrates and relays negative reward signals from forebrain striatal and limbic structures to midbrain monoaminergic centers. LHb aberrant activity (specifically hyperactivity) is also linked to depression. Using whole cell patch clamp recordings in LHb of male wildtype (WT) and ΔPKA knockin mice (with deficiency in AKAP-anchoring of PKA), we found that the genetic disruption of PKA anchoring to AKAP150 significantly reduced AMPA receptor (AMPAR)-mediated glutamatergic transmission and prevented the induction of presynaptic endocannabinoid (eCB)-mediated long-term depression (LTD) in LHb neurons. Moreover, ΔPKA mutation potentiated GABA

Identifiers

PMID38106086
PMCPMC10723374
OpenAlexW4389462555

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.