Evidence map›Paper›PMID 38106074›Full record

ArticlebioRxiv : the preprint server for biology2024

Sexual Dimorphism, Altered Hippocampal Glutamatergic Neurotransmission and Cognitive Impairment in APP Knock-In Mice.

Caleigh A Findley, Samuel A McFadden, Tiarra Hill, Mackenzie R Peck, Kathleen Quinn, Kevin N Hascup, Erin R Hascup

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Caleigh A FindleyNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Depts of Neurology, Springfield, IL, USA.ORCID 0000-0002-8759-1661
Samuel A McFaddenNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Depts of Neurology, Springfield, IL, USA.ORCID 0000-0002-2289-5066
Tiarra HillNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Depts of Neurology, Springfield, IL, USA.
Mackenzie R PeckNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Depts of Neurology, Springfield, IL, USA.ORCID 0000-0002-2611-1150
Kathleen QuinnNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Depts of Neurology, Springfield, IL, USA.
Kevin N HascupNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Depts of Neurology, Springfield, IL, USA.ORCID 0000-0001-6604-1874
Erin R HascupNeuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Depts of Neurology, Springfield, IL, USA.ORCID 0000-0003-1037-0809
Southern Illinois University School of Medicine · US

Funding

Sequelae of SARS-CoV-2 Infection in Alzheimer's DiseaseR01AG061937 · NIA · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI HASCUP, ERIN R · 2018 to 2022
$4.0M
Glutamate neurotransmission in Alzheimer's disease progressionR01AG057767 · NIA · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI HASCUP, ERIN R · 2018 to 2022
$3.2M
NIA NIH HHS R01 AG057767NIA NIH HHS R01 AG061937
6 · The paper itself

Abstract

Background: It is well established that glutamatergic neurotransmission plays an essential role in learning and memory. Previous studies indicate that glutamate dynamics shift with Alzheimer's disease (AD) progression, contributing to negative cognitive outcomes. Objective: In this study, we characterized hippocampal glutamatergic signaling with age and disease progression in a knock-in mouse model of AD (APP Methods: At 2-4 and 18+ months old, male and female APP Results: Glutamate recordings support elevated stimulus-evoked glutamate release in the DG and CA3 of young APP

Indexed as

Alzheimer’s diseaseamyloidcognitionlearningmemorysex differences

Identifiers

PMID38106074
PMCPMC10723272
OpenAlexW4389452181

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.