Evidence map›Paper›PMID 38106071›Full record

ArticleResearch square2023

Single cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the

Kevin Johnston, Bereket B Berackey, Kristine Minh Tran, Alon Gelber, Zhaoxia Yu, Grant MacGregor, Eran A Mukamel, Zhiqun Tan, Kim Green, Xiangmin Xu

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kevin JohnstonUniversity of California Irvine.ORCID https://orcid.org/0000-0002-9381-9212
Bereket B BerackeyUniversity of California Irvine.
Kristine Minh TranUniversity of California Irvine.
Alon GelberUniversity of California San Diego.
Zhaoxia YuUniversity of California Irvine.
Grant MacGregorUniversity of California Irvine.
Eran A MukamelUniversity of California San Diego.
Zhiqun TanUniversity of California Irvine.
Kim GreenUniversity of California Irvine.
Xiangmin XuUniversity of California Irvine.
University of California, Irvine · USUniversity of California San Diego · US

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2017 to 2026
$71.9M
Cell-type-specific neural circuit connectomes in the mouse models of aging and Alzheimer's diseaseU01AG076791 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, ERAN A MUKAMEL · 2022 to 2026
$13.6M
Single-cell transcriptomic and epigenomic analysis of brain cell vulnerabilities to tauopathies in early AD impacted brain regionsR01AG082127 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MICHAEL D KOOB, Bing Ren · 2023 to 2026
$8.1M
Epigenomic analysis of neural circuits in Alzheimer's disease mouse modelsR01AG067153 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI REN, BING, XU, XIANGMIN · 2020 to 2024
$3.8M
Neural circuit mechanisms underlying AD-related memory impairmentsRF1AG065675 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2020 to 2020
$1.9M
NIA NIH HHS R01 AG067153NIA NIH HHS R01 AG082127NIA NIH HHS RF1 AG065675NIA NIH HHS U01 AG076791NIA NIH HHS U54 AG054349
6 · The paper itself

Abstract

introductionThe R47H missense mutation of the TREM2 gene is a strong risk factor for development of Alzheimer's Disease. We investigate cell-type-specific spatial transcriptomic changes induced by the

methodsWe profiled 15 mouse brain sections consisting of wild-type,

resultsThe

conclusionSpatial transcriptomics analysis identifies glial and neuronal transcriptomic alterations induced independently by 5xFAD and

Indexed as

5xFADAstrocytesBDNF signalingMicrogliaNeuronsTREM2

Identifiers

PMID38106071
PMCPMC10723554
OpenAlexW4389434570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.