Evidence map›Paper›PMID 38106063›Full record

ArticlebioRxiv : the preprint server for biology2023

Beta and theta oscillations track effort and previous reward in human basal ganglia and prefrontal cortex during decision making.

Colin W Hoy, Coralie de Hemptinne, Sarah S Wang, Catherine J Harmer, Mathew A J Apps, Masud Husain, Philip A Starr, Simon Little

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Colin W HoyDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-7422-2544
Coralie de HemptinneNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Sarah S WangDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Catherine J HarmerDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0002-1609-8335
Mathew A J AppsDepartment of Experimental Psychology, University of Oxford, Oxford, UK.ORCID 0000-0001-5793-2202
Masud HusainDepartment of Experimental Psychology, University of Oxford, Oxford, UK.ORCID 0000-0002-6850-9255
Philip A StarrDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Simon LittleDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6249-6230
University of California, San Francisco · USUniversity of Oxford · GBUniversity of Florida · US

Funding

Uncovering the neurophysiology of motivation in Parkinson™s disease with implanted adaptive brain stimulationK23NS120037 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LITTLE, SIMON · 2021 to 2024
$809k
Identifying the neural mechanisms of goal-directed decision-making in Parkinson's disease using closed-loop deep brain stimulationF32MH132174 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOY, COLIN · 2023 to 2025
$232k
NIMH NIH HHS F32 MH132174NINDS NIH HHS K23 NS120037Wellcome Trust
6 · The paper itself

Abstract

Choosing whether to exert effort to obtain rewards is fundamental to human motivated behavior. However, the neural dynamics underlying the evaluation of reward and effort in humans is poorly understood. Here, we investigate this with chronic intracranial recordings from prefrontal cortex (PFC) and basal ganglia (BG; subthalamic nuclei and globus pallidus) in people with Parkinson's disease performing a decision-making task with offers that varied in levels of reward and physical effort required. This revealed dissociable neural signatures of reward and effort, with BG beta (12-20 Hz) oscillations tracking subjective effort on a single trial basis and PFC theta (4-7 Hz) signaling previous trial reward. Stimulation of PFC increased overall acceptance of offers in addition to increasing the impact of reward on choices. This work uncovers oscillatory mechanisms that guide fundamental decisions to exert effort for reward across BG and PFC, as well as supporting a causal role of PFC for such choices.

Identifiers

PMID38106063
PMCPMC10723308
OpenAlexW4389406016

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.