Evidence map›Paper›PMID 38106046›Full record

ArticlebioRxiv : the preprint server for biology2024

Social cognitive regions of human association cortex are selectively connected to the amygdala.

Donnisa Edmonds, Joseph J Salvo, Nathan Anderson, Maya Lakshman, Qiaohan Yang, Kendrick Kay, Christina Zelano, Rodrigo M Braga

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Donnisa EdmondsDepartment of Neurology, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-4386-2191
Joseph J SalvoDepartment of Neurology, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-5709-7638
Nathan AndersonDepartment of Neurology, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-5781-0042
Maya LakshmanDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Qiaohan YangDepartment of Neurology, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-9060-5825
Kendrick KayDepartment of Radiology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-6604-9155
Christina ZelanoDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Rodrigo M BragaDepartment of Neurology, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-2671-7096
Northwestern University · USUniversity of Minnesota · US

Funding

Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VASSAR, ROBERT J · 1996 to 2020
$28.9M
Research Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR · 2021 to 2026
$26.3M
TRAINING PROGRAM IN THE NEUROSCIENCE OF HUMAN COGNITIONT32NS047987 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Rodrigo M Braga, Christina Maria Zelano · 2006 to 2026
$5.6M
CAUSAL MECHANISMS OF DISTRIBUTED BRAIN NETWORK FUNCTION DURING EPISODIC MEMORY RETRIEVALR00MH117226 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BRAGA, RODRIGO M · 2020 to 2022
$744k
NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG072977NIMH NIH HHS R00 MH117226NINDS NIH HHS T32 NS047987
6 · The paper itself

Abstract

Reasoning about someone's thoughts and intentions - i.e., forming a theory of mind - is an important aspect of social cognition that relies on association areas of the brain that have expanded disproportionately in the human lineage. We recently showed that these association zones comprise parallel distributed networks that, despite occupying adjacent and interdigitated regions, serve dissociable functions. One network is selectively recruited by theory of mind processes. What circuit properties differentiate these parallel networks? Here, we show that social cognitive association areas are intrinsically and selectively connected to regions of the anterior medial temporal lobe that are implicated in emotional learning and social behaviors, including the amygdala at or near the basolateral complex and medial nucleus. The results suggest that social cognitive functions emerge through coordinated activity between amygdala circuits and a distributed association network, and indicate the medial nucleus may play an important role in social cognition in humans.

Indexed as

accessory basal nucleiAmygdalabasolateral complexdefault networkfunctional connectivityhigh-resolution 7T functional magnetic resonance imaging (fMRI)humanmedial nucleussocial cognitiontheory of mind

Identifiers

PMID38106046
PMCPMC10723387
OpenAlexW4389443056

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.