Evidence map›Paper›PMID 38106031›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Investigation of genomic and transcriptomic risk factors in clopidogrel response in African Americans.

Guang Yang, Cristina Alarcon, Catherine Chanfreau, Norman H Lee, Paula Friedman, Edith Nutescu, Matthew Tuck, Travis O'Brien, Li Gong, Teri E Klein and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

Guang YangDepartment of Pharmacology, Center for Pharmacogenomics, Fienberg School of Medicine, Northwestern University, Chicago IL.
Cristina AlarconDepartment of Pharmacology, Center for Pharmacogenomics, Fienberg School of Medicine, Northwestern University, Chicago IL.
Catherine ChanfreauVA Salt Lake City Heath Care System, Salt Lake City, UT.
Norman H LeeDepartment of Pharmacology and Physiology, George Washington University, 2300 I Street NW, Washington, DC, 20037, USA.
Paula FriedmanDepartment of Pharmacology, Center for Pharmacogenomics, Fienberg School of Medicine, Northwestern University, Chicago IL.
Edith NutescuDepartment of Pharmacy Practice and Center for Pharmacoepidemiology and Pharmacoeconomic Research, University of Illinois Chicago, College of Pharmacy, Chicago, IL.ORCID 0000-0002-2651-0020
Matthew TuckWashington DC VA Medical Center, Washington, DC and The George Washington University, Washington, DC.ORCID 0000-0002-5991-0709
Travis O'BrienDepartment of Pharmacology and Physiology, George Washington University, 2300 I Street NW, Washington, DC, 20037, USA.
Li GongDepartment of Biomedical Data Science, Stanford University, Stanford, CA.
Teri E KleinDepartment of Biomedical Data Science and Department of Medicine, Stanford University, Stanford, CA.ORCID 0000-0001-5527-6475
Kyong-Mi ChangCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA.ORCID 0000-0001-6811-9364
Philip S TsaoVA Palo Alto Healthcare System and Stanford University, Palo Alto, CA.ORCID 0000-0001-7274-9318
David O MeltzerSection of Hospital Medicine, Department of Medicine, University of Chicago, Chicago, IL.
Million Veteran Program
Sony TutejaCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA.ORCID 0000-0001-7007-3289
Minoli A PereraDepartment of Pharmacology, Center for Pharmacogenomics, Fienberg School of Medicine, Northwestern University, Chicago IL.ORCID 0000-0002-1146-2791
Northwestern University · USGeorge Washington University · USPhiladelphia VA Medical Center · USStanford University · USUniversity of Chicago · USUniversity of Illinois Urbana-Champaign · USVA Palo Alto Health Care System · USVA Salt Lake City Healthcare System · US

Funding

African American Cardiovascular pharmacogenetic CONsorTium (ACCOuNT): discovery and translationU54MD010723 · NIMHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MELTZER, DAVID O, PERERA, MINOLI A · 2016 to 2020
$9.5M
PharmGKB: pharmacogenomics discovery and implementationU24HG010615 · NHGRI · STANFORD UNIVERSITY · PI TERI Ellen KLEIN, Michelle Whirl-Carrillo · 2020 to 2026
$9.5M
Genetics of Cardiometabolic Diseases in the VA PopulationI01BX003362 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI Kyong-Mi Chang, Philip S Tsao · 2017 to 2026
–
BLRD VA I01 BX003362NHGRI NIH HHS U24 HG010615NIMHD NIH HHS U54 MD010723
6 · The paper itself

Abstract

Clopidogrel, an anti-platelet drug, used to prevent thrombosis after percutaneous coronary intervention. Clopidogrel resistance results in recurring ischemic episodes, with African Americans suffering disproportionately. The aim of this study was to identify biomarkers of clopidogrel resistance in African American patients. We conducted a genome-wide association study, including local ancestry adjustment, in 141 African Americans on clopidogrel to identify associations with high on-treatment platelet reactivity (HTPR). We validated genome-wide and suggestive hits in an independent cohort of African American clopidogrel patients (N = 823) from the Million Veteran's Program (MVP) along with in vitro functional follow up. We performed differential gene expression (DGE) analysis in whole blood with functional follow-up in MEG-01 cells. We identified rs7807369, within thrombospondin 7A (

Identifiers

PMID38106031
PMCPMC10723512
OpenAlexW4389426088

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.