Evidence map›Paper›PMID 38106016›Full record

ArticlebioRxiv : the preprint server for biology2024

Queuosine Salvage in

Samia Quaiyum, Yifeng Yuan, Guangxin Sun, R M Madhushi N Ratnayake, Geoffrey Hutinet, Peter C Dedon, Michael F Minnick, Valérie de Crécy-Lagard

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Samia QuaiyumDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611.
Yifeng YuanDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611.
Guangxin SunDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
R M Madhushi N RatnayakeDepartment of Chemistry, University of Florida, Gainesville, FL 32611.
Geoffrey HutinetDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611.
Peter C DedonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0003-0011-3067
Michael F MinnickDivision of Biological Sciences, University of Montana, Missoula, Montana, MT 59812.
Valérie de Crécy-LagardDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611.ORCID 0000-0002-9955-3785
University of Florida · USMassachusetts Institute of Technology · USUniversity of Montana · US

Funding

Synthesis and function of Queuosine in BacteriaR01GM070641 · NIGMS · UNIVERSITY OF FLORIDA · PI DE CRECY-LAGARD, VALERIE A · 2006 to 2023
$5.3M
Translational regulation in exposure biology: Xenobiotic-induced reprograming oftRNA modifications and selective translation of codon-biased response genes in rat and humanmodelsR01ES026856 · NIEHS · SUNY POLYTECHNIC INSTITUTE · PI Thomas J Begley, Peter C Dedon · 2016 to 2026
$3.9M
Translational Control of ROS ManagementR01ES024615 · NIEHS · SUNY POLYTECHNIC INSTITUTE · PI BEGLEY, THOMAS J · 2014 to 2018
$1.8M
NIEHS NIH HHS R01 ES024615NIEHS NIH HHS R01 ES026856NIGMS NIH HHS R01 GM070641
6 · The paper itself

Abstract

Queuosine (Q) stands out as the sole tRNA modification that can be synthesized via salvage pathways. Comparative genomic analyses identified specific bacteria that showed a discrepancy between the projected Q salvage route and the predicted substrate specificities of the two identified salvage proteins: 1) the distinctive enzyme tRNA guanine-34 transglycosylase (bacterial TGT, or bTGT), responsible for inserting precursor bases into target tRNAs; and 2) Queuosine Precursor Transporter (QPTR), a transporter protein that imports Q precursors. Organisms like the facultative intracellular pathogen

Indexed as

Bartonella henselaeintracellular parasiteQueuosineTGT enzymetRNA modificationYhhQ

Identifiers

PMID38106016
PMCPMC10723273
OpenAlexW4389451422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.