Evidence map›Paper›PMID 38106015›Full record

ArticlebioRxiv : the preprint server for biology2023

Coevolution with toxic prey produces functional trade-offs in sodium channels of predatory snakes.

Robert E Del Carlo, Jessica S Reimche, Haley A Moniz, Michael T J Hague, Shailesh R Agarwal, Edmund D Brodie, Edmund D Brodie, Normand Leblanc, Chris R Feldman

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Robert E Del CarloUniversity of Nevada, Reno School of Medicine, Department of Pharmacology, Reno, Nevada, USA, 89557.ORCID 0000-0003-4845-7037
Jessica S ReimcheUniversity of Nevada, Reno, Department of Biology, Reno, Nevada, USA, 89557.
Haley A MonizUniversity of Nevada, Reno, Department of Biology, Reno, Nevada, USA, 89557.
Michael T J HagueUniversity of Virginia, Department of Biology, Charlottesville, Virginia, USA, 22904.
Shailesh R AgarwalUniversity of Nevada, Reno School of Medicine, Department of Pharmacology, Reno, Nevada, USA, 89557.
Edmund D BrodieUniversity of Virginia, Department of Biology, Charlottesville, Virginia, USA, 22904.
Edmund D BrodieUtah State University, Department of Biology, Logan, Utah, USA, 84322.
Normand LeblancUniversity of Nevada, Reno School of Medicine, Department of Pharmacology, Reno, Nevada, USA, 89557.
Chris R FeldmanUniversity of Nevada, Reno, Department of Biology, Reno, Nevada, USA, 89557.
University of Nevada, Reno · USUtah State University · USUniversity of Virginia · US

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Nathan Grainger · 2019 to 2026
$20.3M
Bestrophin Channel Function in HeartR01HL091238 · NHLBI · UNIVERSITY OF NEVADA RENO · PI BRITTON, FIONA CATHERINE · 2008 to 2012
$2.0M
Regulation of compartmentalized cAMP signaling by mitochondria-associated spaces in adult ventricular myocytesR01HL161122 · NHLBI · UNIVERSITY OF NEVADA RENO · PI AGARWAL, SHAILESH · 2022 to 2025
$1.8M
NHLBI NIH HHS R01 HL091238NHLBI NIH HHS R01 HL161122NIGMS NIH HHS P20 GM130459
6 · The paper itself

Abstract

Seemingly unrelated traits often share the same underlying molecular mechanisms, potentially generating a pleiotropic relationship whereby selection shaping one trait can simultaneously compromise another. While such functional trade-offs are expected to influence evolutionary outcomes, their actual relevance in nature is masked by obscure links between genotype, phenotype, and fitness. Here, we describe functional trade-offs that likely govern a key adaptation and coevolutionary dynamics in a predator-prey system. Several garter snake (

Indexed as

AdaptationAntagonistic PleiotropyConstraintsMolecular EvolutionPhenotypic IntegrationToxin Resistance

Identifiers

PMID38106015
PMCPMC10723449
OpenAlexW4389555667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.