Evidence map›Paper›PMID 38106011›Full record

ArticlebioRxiv : the preprint server for biology2023

The Effect of Pseudoknot Base Pairing on Cotranscriptional Structural Switching of the Fluoride Riboswitch.

Laura M Hertz, Elise N White, Konstantin Kuznedelov, Luyi Cheng, Angela M Yu, Rivaan Kakkaramadam, Konstantin Severinov, Alan Chen, Julius B Lucks

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Laura M HertzInterdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-4493-3542
Elise N WhiteDepartment of Chemistry and the RNA Institute, University at Albany, Albany, NY 12222, USA.ORCID 0000-0002-1299-9646
Konstantin KuznedelovWaksman Institute of Microbiology, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0002-9040-3895
Luyi ChengInterdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-4543-1915
Angela M YuDepartment of Electrical and Computer Engineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-5404-594X
Rivaan KakkaramadamDepartment of Chemistry and the RNA Institute, University at Albany, Albany, NY 12222, USA.ORCID 0009-0003-3005-0164
Konstantin SeverinovWaksman Institute of Microbiology, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0001-9706-450X
Alan ChenDepartment of Chemistry and the RNA Institute, University at Albany, Albany, NY 12222, USA.ORCID 0000-0001-8246-2935
Julius B LucksInterdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0619-6505
Northwestern University · USUniversity at Albany, State University of New York · USRutgers, The State University of New Jersey · USUniversity of Washington · US

Funding

Developing Capacity to Evaluate Training Programs via Development of Human, Institutional and Social CapitalT32GM008449 · NIGMS · NORTHWESTERN UNIVERSITY · PI LEONARD, JOSHUA NATHANIEL · 1993 to 2023
$7.8M
Tri-Institutional Training Program in Computational Biology & MedicineT32GM083937 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHRISTINI, DAVID J. · 2009 to 2018
$3.1M
NIGMS NIH HHS T32 GM008449NIGMS NIH HHS T32 GM083937
6 · The paper itself

Abstract

A central question in biology is how RNA sequence changes influence dynamic conformational changes during cotranscriptional folding. Here we investigated this question through the study of transcriptional fluoride riboswitches, non-coding RNAs that sense the fluoride anion through the coordinated folding and rearrangement of a pseudoknotted aptamer domain and a downstream intrinsic terminator expression platform. Using a combination of

Identifiers

PMID38106011
PMCPMC10723315
OpenAlexW4389395733

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.