ArticlebioRxiv : the preprint server for biology2023
Rapid and Quantitative Functional Interrogation of Human Enhancer Variant Activity in Live Mice.
Ethan W Hollingsworth, Taryn A Liu, Sandra H Jacinto, Cindy X Chen, Joshua A Alcantara, Evgeny Z Kvon
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
Ethan W HollingsworthDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.ORCID 0000-0002-5188-3929 Taryn A LiuDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.
Sandra H JacintoDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.
Cindy X ChenDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.
Joshua A AlcantaraDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.
Evgeny Z KvonDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.ORCID 0000-0002-1562-0945 Funding
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1MTraining Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3MDeciphering the mechanism of long-range gene regulation in vivoDP2GM149555 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KVON, EVGENY · 2022 to 2025
$2.4MHigh-Throughput DNA SequencerS10OD021718 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2016 to 2016
$600kPacBio RS Single Molecule, Real-Time (SMRT) DNA SequencerS10OD010794 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2012 to 2012
$600kHigh Throughput DNA SequencerS10RR025496 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2009 to 2009
$500kDeciphering Mechanisms of Limb Malformations Caused by Noncoding Variants In VivoF30HD110233 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI Ethan W Hollingsworth · 2022 to 2026
$189kNCI NIH HHS P30 CA062203NCRR NIH HHS S10 RR025496NICHD NIH HHS F30 HD110233NIGMS NIH HHS DP2 GM149555NIGMS NIH HHS T32 GM008620NIH HHS S10 OD010794NIH HHS S10 OD021718NINDS NIH HHS T32 NS082174
6 · The paper itselfAbstract
Functional analysis of non-coding variants associated with human congenital disorders remains challenging due to the lack of efficient
Indexed as
cis-regulatory elementenhancer variantMouse TransgenesisZRS
Identifiers
PMID38105996
PMCPMC10723448
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