Evidence map›Paper›PMID 38105992›Full record

ArticlebioRxiv : the preprint server for biology2025

Single-cell transcriptional changes across the blood stages of artemisinin-resistant K13

Cliff I Oduor, Sean V Connelly, Clark Cunningham, Ian Petrow, Nazrin Rustamzade, Jenna Zuromski, Deborah M Chin, Christian P Nixon, Jonathan D Kurtis, Jonathan J Juliano and 1 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Cliff I OduorDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.ORCID 0000-0002-6914-4032
Sean V ConnellyDivision of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-7330-7340
Clark CunninghamDivision of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Ian PetrowDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Nazrin RustamzadeDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Jenna ZuromskiDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Deborah M ChinDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Christian P NixonDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.ORCID 0000-0002-9243-5567
Jonathan D KurtisDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.ORCID 0000-0003-1032-9558
Jonathan J JulianoDivision of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-0591-0850
Jeffrey A BaileyDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.ORCID 0000-0002-6899-8204
Brown University · USUniversity of North Carolina at Chapel Hill · USRhode Island Department of Health · US

Funding

Variation in Resistance and Fitness to Artemisinins in African MalariaR01AI121558 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, JONATHAN J · 2016 to 2020
$3.3M
Artemisinin Resistance in Africa: its emergence and evolution in RwandaR01AI156267 · NIAID · BROWN UNIVERSITY · PI BAILEY, JEFFREY A., JULIANO, JONATHAN J · 2021 to 2024
$3.0M
Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
Investigating the molecular mechanisms of Plasmodium vivax invasion in Duffy-negative hostsF30AI183592 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sean Connelly · 2024 to 2026
$130k
NIAID NIH HHS F30 AI183592NIAID NIH HHS K24 AI134990NIAID NIH HHS R01 AI121558NIAID NIH HHS R01 AI156267
6 · The paper itself

Abstract

Artemisinin-based therapies have been central to malaria control, but partial resistance in

Indexed as

artemisinindihydroartemisinindrug resistanceKelch13Plasmodium falciparumRNA-seqSingle-cellTranscriptome

Identifiers

PMID38105992
PMCPMC10723473
OpenAlexW4389408800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.