Evidence map›Paper›PMID 38105991›Full record

ArticlebioRxiv : the preprint server for biology2023

The Effects of Preeclamptic Milieu on Cord Blood Derived Endothelial Colony-Forming Cells.

Eva Hall, Laura Alderfer, Erin Neu, Sanjoy Saha, Ellie Johandes, David M Haas, Laura S Haneline, Donny Hanjaya-Putra

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Eva HallAerospace and Mechanical Engineering, Bioengineering Graduate Program, University of Notre Dame.ORCID 0000-0002-0091-1045
Laura AlderferAerospace and Mechanical Engineering, Bioengineering Graduate Program, University of Notre Dame.
Erin NeuDepartment of Obstetrics & Gynecology, Indiana University School of Medicine, Indianapolis, IN.
Sanjoy SahaAerospace and Mechanical Engineering, Bioengineering Graduate Program, University of Notre Dame.
Ellie JohandesAerospace and Mechanical Engineering, Bioengineering Graduate Program, University of Notre Dame.
David M HaasDepartment of Obstetrics & Gynecology, Indiana University School of Medicine, Indianapolis, IN.
Laura S HanelineHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN.
Donny Hanjaya-PutraAerospace and Mechanical Engineering, Bioengineering Graduate Program, University of Notre Dame.ORCID 0000-0002-5403-544X
University of Notre Dame · USIndiana University School of MedicineIndiana University Health · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Jun Wan · 1999 to 2026
$59.3M
Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
Engineering the Stem Cell Microenvironment for Lymphatic RegenerationR35GM143055 · NIGMS · UNIVERSITY OF NOTRE DAME · PI HANJAYA-PUTRA, DONNY · 2021 to 2025
$2.2M
Endothelial Progenitor and Vascular Dysfunction in Infants of Diabetic MothersR01HL094725 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI HANELINE, LAURA S · 2009 to 2012
$1.5M
NCI NIH HHS P30 CA082709NHLBI NIH HHS R01 HL094725NIDDK NIH HHS U54 DK106846NIGMS NIH HHS R35 GM143055
6 · The paper itself

Abstract

Preeclampsia is one of the leading causes of infant and maternal mortality worldwide. Many infants born from preeclamptic pregnancies are born prematurely with higher risk of developing cardiovascular later in their life. A key mechanism by which these complications occur is through stress-induced dysfunction of endothelial progenitor cells (EPCs), including endothelial colony-forming cells (ECFCs). To gain insight into this, cord blood derived ECFCs isolated from preeclamptic pregnancies (PRECs) were analyzed and compared to their healthy counterparts. While PRECs preserve key endothelial markers, they upregulate several markers associated with oxidative stress and inflammatory response. Compared to ECFCs, PRECs also exhibit lower migratory behaviors and impaired angiogenic potential. Interestingly, treatment of neuropilin-1 can improve tube formation

Identifiers

PMID38105991
PMCPMC10723349
OpenAlexW4389332021

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.