Evidence map›Paper›PMID 38105982›Full record

ArticlebioRxiv : the preprint server for biology2023

UBE2N is essential for maintenance of skin homeostasis and suppression of inflammation.

Min Jin Lee, Manel Ben Hammouda, Wanying Miao, Arinze Okafor, Yingai Jin, Huiying Sun, Vaibhav Jain, Vadim Markovtsov, Yarui Diao, Simon G Gregory and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Min Jin LeeDepartment of Dermatology, Duke University, Durham, NC, USA.ORCID 0000-0002-9804-3193
Manel Ben HammoudaDepartment of Dermatology, Duke University, Durham, NC, USA.ORCID 0000-0002-6625-7744
Wanying MiaoDepartment of Dermatology, Duke University, Durham, NC, USA.ORCID 0000-0003-3972-2572
Arinze OkaforDepartment of Cell Biology, Duke University, Durham, NC, USA.ORCID 0000-0002-3416-1350
Yingai JinDepartment of Dermatology, Duke University, Durham, NC, USA.ORCID 0000-0003-0384-0796
Huiying SunDepartment of Dermatology, Duke University, Durham, NC, USA.ORCID 0000-0003-1162-5228
Vaibhav JainDuke Molecular Physiology Institute, Durham, NC, USA.
Vadim MarkovtsovRigel Pharmaceuticals, South San Francisco, CA, USA.ORCID 0009-0004-6864-6809
Yarui DiaoDepartment of Cell Biology, Duke University, Durham, NC, USA.ORCID 0000-0001-5842-4082
Simon G GregoryDuke Molecular Physiology Institute, Durham, NC, USA.ORCID 0000-0002-7805-1743
Jennifer Y ZhangDepartment of Dermatology, Duke University, Durham, NC, USA.ORCID 0000-0002-4485-1750
Duke University · USDuke Medical Center · USRigel (United States) · US

Funding

UBE2N/UBE2V1 as a vulnerable link between keratinocytes and myeloid cellsR01AR073858 · NIAMS · DUKE UNIVERSITY · PI Jennifer Yunyan Zhang · 2019 to 2026
$2.1M
NIAMS NIH HHS R01 AR073858
6 · The paper itself

Abstract

UBE2N, a Lys63-ubiquitin conjugating enzyme, plays critical roles in embryogenesis and immune system development and function. However, its roles in adult epithelial tissue homeostasis and pathogenesis are unclear. We generated conditional mouse models that deleted

Indexed as

cutaneous biologyIL-1 signalinginflammationskin immunologyUBE2N

Identifiers

PMID38105982
PMCPMC10723344
OpenAlexW4389296538

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.