Evidence map›Paper›PMID 38105975›Full record

ArticlebioRxiv : the preprint server for biology2023

Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function.

Catharina R Grubaugh, Anuradha Dhingra, Binu Prakash, Diego Montenegro, Janet R Sparrow, Lauren L Daniele, Christine A Curcio, Brent A Bell, M Mahmood Hussain, Kathleen Boesze-Battaglia

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Catharina R GrubaughDepartment of Basic and Translational Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Anuradha DhingraDepartment of Basic and Translational Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Binu PrakashDepartment of Foundations of Medicine, New York University Grossman Long Island School of Medicine, Mineola, NY, 11501 USA.
Diego MontenegroDepartment of Ophthalmology and Department of Pathology and Cell Biology, Columbia University, New York, NY,10027 USA.
Janet R SparrowDepartment of Ophthalmology and Department of Pathology and Cell Biology, Columbia University, New York, NY,10027 USA.
Lauren L DanieleDepartment of Basic and Translational Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christine A CurcioDepartment of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Brent A BellDepartment of Ophthalmology, University of Pennsylvania, Philadelphia, PA, 19104 USA.
M Mahmood HussainDepartment of Foundations of Medicine, New York University Grossman Long Island School of Medicine, Mineola, NY, 11501 USA.
Kathleen Boesze-BattagliaDepartment of Basic and Translational Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
California University of Pennsylvania · USColumbia University · USLong Island University · USUniversity of Alabama at Birmingham · US

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Qi N Cui · 1985 to 2026
$19.5M
Novel regulatory mechanisms controlling hepatic apoB-Lp lipid loading and secretionP01HL160470 · NHLBI · NYU LONG ISLAND SCHOOL OF MEDICINE · PI Ira J Goldberg · 2023 to 2026
$12.3M
IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLSR01EY012951 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPARROW, JANET RUTHE · 2000 to 2024
$8.9M
Regulation of plasma LDL and HDL by microRNA-541-3pR01HL166214 · NHLBI · NYU LONG ISLAND SCHOOL OF MEDICINE · PI M Mahmood Hussain · 2023 to 2026
$2.5M
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY012951NHLBI NIH HHS P01 HL160470NHLBI NIH HHS R01 HL166214
6 · The paper itself

Abstract

Lipid processing by the retinal pigment epithelium (RPE) is necessary to maintain retinal health and function. Dysregulation of retinal lipid homeostasis due to normal aging or to age-related disease triggers lipid accumulation within the RPE, on Bruch's membrane (BrM), and in the subretinal space. In its role as a hub for lipid trafficking into and out of the neural retina, the RPE packages a significant amount of lipid into lipid droplets for storage and into apolipoprotein B (apoB)-containing lipoproteins (Blps) for export. Microsomal triglyceride transfer protein (MTP), encoded by the

Indexed as

apoB containing-lipoproteincholesterollipid steatosislipoid degenerationmicrosomal triglyceride transfer proteinretinal degenerationretinal functionretinal pigment epitheliumsub-retinal deposits

Identifiers

PMID38105975
PMCPMC10723417
OpenAlexW4389452115

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.