Evidence map›Paper›PMID 38105947›Full record

ArticleResearch square2023

The Greatwall-Endosulfine-PP2A/B55 pathway controls entry into quiescence by promoting translation of Elongator-tuneable transcripts.

Javier Encinar Del Dedo, Rafael López-San Segundo, Alicia Vázquez-Bolado, Jingjing Sun, Natalia García-Blanco, M Belén Suárez, Patricia García, Pauline Tricquet, Jun-Song Chen, Peter C Dedon and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Javier Encinar Del DedoInstituto de Biología Funcional y Genómica, CSIC, University of Salamanca, 37007 Salamanca, Spain.
Rafael López-San SegundoInstituto de Biología Funcional y Genómica, CSIC, University of Salamanca, 37007 Salamanca, Spain.
Alicia Vázquez-BoladoInstituto de Biología Funcional y Genómica, CSIC, University of Salamanca, 37007 Salamanca, Spain.
Jingjing SunAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.
Natalia García-BlancoInstituto de Biología Funcional y Genómica, CSIC, University of Salamanca, 37007 Salamanca, Spain.
M Belén SuárezInstituto de Biología Funcional y Genómica, University of Salamanca, CSIC, 37007 Salamanca, Spain.
Patricia GarcíaInstituto de Biología Funcional y Genómica, University of Salamanca, CSIC, 37007 Salamanca, Spain.ORCID https://orcid.org/0000-0001-7513-1847
Pauline TricquetURPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000, Belgium.
Jun-Song ChenDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, United States.
Peter C DedonAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.ORCID https://orcid.org/0000-0003-0011-3067
Kathleen L GouldDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, United States.
Elena HidalgoOxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, 08003 Barcelona, Spain.ORCID https://orcid.org/0000-0002-3768-6785
Damien HermandURPHYM-GEMO, University of Namur, rue de Bruxelles, 61, Namur 5000, Belgium.ORCID https://orcid.org/0000-0002-1029-5848
Sergio MorenoInstituto de Biología Funcional y Genómica, CSIC, University of Salamanca, 37007 Salamanca, Spain.ORCID https://orcid.org/0000-0002-8039-1413
Universidad de Salamanca · ESUniversity of Namur · BEVanderbilt University · USCenter for Environmental Health · USSingapore-MIT Alliance for Research and Technology · SGUniversitat Pompeu Fabra · ES

Funding

Regulation of cytokinesisR35GM131799 · NIGMS · VANDERBILT UNIVERSITY · PI Kathleen L Gould · 2019 to 2026
$6.4M
NIGMS NIH HHS R35 GM131799
6 · The paper itself

Abstract

Quiescent cells require a continuous supply of proteins to maintain protein homeostasis. In fission yeast, entry into quiescence is triggered by nitrogen stress, leading to the inactivation of TORC1 and the activation of TORC2. Here, we report that the Greatwall-Endosulfine-PPA/B55 pathway connects the downregulation of TORC1 with the upregulation of TORC2, resulting in the activation of Elongator-dependent tRNA modifications essential for sustaining the translation programme during entry into quiescence. This process promotes U

Indexed as

ElongatorEndosulfineGreatwallNitrogen starvationPP2A/B55QuiescenceTORC1TORC2translationtRNA modifications

Identifiers

PMID38105947
PMCPMC10723533
OpenAlexW4389322610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.