ArticleJournal of affective disorders reports2023
Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala.
Article in Journal of affective disorders reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Perturbed Inflammatory, Proliferation, Regulatory, And Neurodegeneration Signaling Pathways Are Associated With Trait Anxiety In Cancer Survivors.Research square · 2026Article
- Article
- The Interplay of Food Insecurity, Resilience, Stress Mindset, and Mental Distress: Insights From a Cross-Sectional Study.Health science reports · 2025Article
- DSAM: A deep learning framework for analyzing temporal and spatial dynamics in brain networks.Medical image analysis · 2025Article
- Sex Based Comparison of Health Self-Perception, Sleep, Anxiety, and Body Composition Among University Students.International journal of public health · 2025Article
- Examining anterior prefrontal cortex resting-state functional connectivity patterns associated with depressive symptoms in chronic moderate-to-severe traumatic brain injury.Frontiers in neurology · 2025Article
- Characterising the anxiogenic network from functional connectivity analysis of the COScientific reports · 2024Article
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Authors and funding
6 authors.
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Abstract
Background: Numerous studies characterized how resting-state functional connectivities (rsFCs) of the amygdala were disrupted in emotional disorders and varied with emotional traits, including anxiety. With trait anxiety known to diminish with age, a critical issue concerns disambiguating the effects of age and anxiety on amygdala rsFCs in studying the neural bases of individual differences in anxiety. Methods: Two-hundred adults (83 women) 19-85 years of age underwent fMRI and assessment for trait anxiety. Amygdala rsFC correlates were identified using multiple regression with age and anxiety in the same model for all and separately in men and women. The rsFC correlates were examined for age-anxiety interaction. Results: Anxiety was negatively correlated with amygdala-temporooccipital gyri rsFC in all and in men alone. In women, amgydala rsFC with the thalamus/pallidum, angular/supramarginal gyri, inferior temporal gyrus, and posterior insula correlated positively and rsFC with calcarine cortex and caudate correlated negatively with anxiety. We also observed sex differences in age correlation of amgydala-posterior cingulate cortex/precuneus and -insula/temporoparietal rsFCs, with stronger associations in women. In women alone, anxiety and age interacted to determine amygdala rsFC with the thalamus/pallidum, calcarine cortex, and caudate, with older age associated with stronger correlation between anxiety and the rsFCs. Limitations: The findings need to be validated in an independent sample and further explored using task-based data. Conclusion: Highlighting anxiety- and age- specific as well as interacting correlates of amygdala rsFCs and sex differences in the correlates, the findings may shed light on the neural markers of anxiety.
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