Evidence map›Paper›PMID 38105605›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative.

Erlan Sanchez, Tim Wilkinson, Gillian Coughlan, Saira Mirza, Andrée-Ann Baril, Joel Ramirez, Malcolm A Binns, Sandra E Black, Michael Borrie, Allison A Dilliott and 34 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 7 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 7 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Elevated neurofilament light chain (NfL) in blood and CSF as a biomarker for Parkinson's disease cognitive impairment: A meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  9. The enigma of vascular dementia: current state and emerging perspectives.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 19 institutions in 4 countries.

Erlan SanchezL.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Tim WilkinsonL.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Gillian CoughlanDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Saira MirzaL.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Andrée-Ann BarilDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Joel RamirezDr. Sandra Black Centre for Brain Resilience & Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Malcolm A BinnsRotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
Sandra E BlackDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Michael BorrieLawson Health Research Institute, London, Ontario, Canada.
Allison A DilliottDepartment of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
Roger A DixonDepartment of Psychology, Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
Dar DowlatshahiDepartment of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Sali FarhanDepartment of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
Elizabeth FingerLawson Health Research Institute, London, Ontario, Canada.
Corinne E FischerKeenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Andrew FrankBruyere Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Morris FreedmanDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Rafaella A GoncalvesCentre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
David A GrimesDepartment of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Ayman HassanThunder Bay Regional Research Institute, Northern Ontario School of Medicine, Thunder Bay, Ontario, Canada.
Robert A HegeleSchulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Sanjeev KumarCentre for Addiction and Mental Health, Toronto, Ontario, Canada.
Anthony E LangDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Connie MarrasEdmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada.
Paula M McLaughlinNova Scotia Health, Halifax, Nova Scotia, Canada.
Joseph B OrangeSchool of Communication Sciences and Disorders, Western University, London, Ontario, Canada.
Stephen H PasternakDepartment of Clinical Neurological Sciences, Robarts Research Institute, Western University, London, Ontario, Canada.
Bruce G PollockCentre for Addiction and Mental Health, Toronto, Ontario, Canada.
Tarek K RajjiCentre for Addiction and Mental Health, Toronto, Ontario, Canada.
Angela C RobertsSchool of Communication Sciences and Disorders, Western University, London, Ontario, Canada.
John F RobinsonSchulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Ekaterina RogaevaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
Demetrios J SahlasMcMaster University, Hamilton, Ontario, Canada.
Gustavo SaposnikDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Michael J StrongSchulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Richard H SwartzDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
David F Tang-WaiDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
Angela K TroyerDepartment of Psychology, University of Toronto, Toronto, Ontario, Canada.
Hlin KvartsbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Douglas P MunozCentre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
ONDRI Investigators
Mario MasellisL.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Western University · CASunnybrook Health Science Centre · CAUniversity of Toronto · CACentre for Addiction and Mental Health · CAUniversity of Ottawa · CAMontreal Neurological Institute and Hospital · CAQueen's University · CASt. Michael's Hospital · CAUniversity Health Network · CADalhousie University · CADouglas Mental Health University Institute · CAHarvard University · USMcMaster University · CAMount Sinai Hospital · CASahlgrenska University Hospital · SEThunder Bay Regional Research Institute · CAToronto Western Hospital · CAUniversity of Alberta · CAUniversity of Wisconsin–Madison · US

Funding

CIHR #163902
6 · The paper itself

Abstract

introductionWe investigated whether novel plasma biomarkers are associated with cognition, cognitive decline, and functional independence in activities of daily living across and within neurodegenerative diseases.

methodsGlial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau (p-tau)181 and amyloid beta (Aβ)

resultsGFAP, NfL, and/or p-tau181 were elevated among all diseases compared to controls, and were broadly associated with worse baseline cognitive performance, greater cognitive decline, and/or lower functional independence. While GFAP, NfL, and p-tau181 were highly predictive across diseases, p-tau181 was more specific to the AD/MCI cohort. Sparse associations were found in the FTD and CVD cohorts and for Aβ DISCUSSION: GFAP, NfL, and p-tau181 are valuable predictors of cognition and function across common neurodegenerative diseases, and may be useful in specialized clinics and clinical trials.

Indexed as

Alzheimer DiseaseCardiovascular DiseasesCognitive DysfunctionFrontotemporal DementiaNeurodegenerative DiseasesActivities of Daily LivingAmyloid beta-PeptidesBiomarkersCognitionHumansOntariotau ProteinsAmyloid beta-PeptidesBiomarkerstau Proteinsactivities of daily livingamyloidamyloid betabloodblood-basedcognitiondementiaglial fibrillary acidic proteinlongitudinalneurofilament light chainneuropsychiatricphosphorylated tauproteintauvascular

Identifiers

PMID38105605
PMCPMC10984487
OpenAlexW4389862492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.