Evidence map›Paper›PMID 38105357›Full record

ArticleParasitology research2023

Impact of atorvastatin and mesenchymal stem cells combined with ivermectin on murine trichinellosis.

Zeinab R Hassan, Samar El-Sayed, Kareman M Zekry, Samah Gouda Ahmed, Asmaa Hassan Abd-Elhamid, Doaa E A Salama, Azza Kamal Taha, Nihal A Mahmoud, Shaymaa Fathy Mohammed, Mona M Amin and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Zeinab R HassanDepartment of Parasitology, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt. zenabramadan.medg@azhar.edu.eg.ORCID http://orcid.org/0000-0002-6767-6764
Samar El-SayedDepartment of Parasitology, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Kareman M ZekryDepartment of Parasitology, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Samah Gouda AhmedDepartment of Histology, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Asmaa Hassan Abd-ElhamidDepartment of Histology, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Doaa E A SalamaDepartment of Pathology, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Azza Kamal TahaDepartment of Pathology, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Nihal A MahmoudDepartment of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Shaymaa Fathy MohammedDepartment of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Mona M AminDepartment of Pharmacology, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Rasha Elsayed MohamedDepartment of Biochemistry, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Ayat M S EraqueDepartment of Biochemistry, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Shimaa A MohamedDepartment of Biochemistry, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Ranya M AbdelgalilDepartment of Anatomy and Embryology, Faculty of Medicine for Girls, Al-Azhar University, Yosief Abbas Street, Cairo, Kairo, Egypt.
Shimaa Attia AttaDepartment of Immunology, Theodor Bilharz Research Institute, 36VF+MJ2, Warraq Al Arab, El Warraq, Giza Governorate, 3863130, Egypt.
Nermeen Talaat FahmyGenomics, Egypt Center for Research and Regenerative Medicine (ECRRM), 3 Emtedad Ramses, Al Abbaseyah Al Gharbeyah, El Weili, Cairo Governorate, 4435102, Egypt.
Mohamed S BadrMolecular Biology and Genetic-Bioinformatics Nano-Robot Diagnostics, Medical Research Centre, Faculty of Medicine, Ain Shams University, El-Khalyfa El-Mamoun Street Abbasya, Cairo, Egypt.
Al-Azhar University · EGAin Shams University · EGEgypt Center for Research and Regenerative Medicine · EGTheodor Bilharz Research Institute · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trichinellosis is one of the global food-borne parasitic diseases that can cause severe tissue damage. The traditionally used drugs for the treatment of trichinellosis have limited efficacy against the encysted larvae in the muscular phase of the disease. Therefore, this study aimed to evaluate the role of atorvastatin and mesenchymal stem cells combined with ivermectin against different phases of Trichinella in experimentally infected mice. A total of 120 male Swiss albino mice were divided into two major groups (n = 60 of each), intestinal and muscular phases. Then, each group was subdivided into 10 subgroups (n = 6); non-infected control, infected non-treated control, infected ivermectin treated, infected atorvastatin treated, infected mesenchymal stem cells treated, infected combined ivermectin and atorvastatin treated, infected combined mesenchymal stem cells and ivermectin treated, infected combined mesenchymal stem cells and atorvastatin treated, infected combined mesenchymal stem cells and a full dose of (ivermectin and atorvastatin) treated, and infected combined mesenchymal stem cells and half dose of (ivermectin and atorvastatin) treated. Mice were sacrificed at days 5 and 35 post-infection for the intestinal and muscular phases, respectively. The assessment was performed through many parameters, including counting the adult intestinal worms and muscular encysted larvae, besides histopathological examination of the underlying tissues. Moreover, a biochemical assay for the inflammatory and oxidative stress marker levels was conducted. In addition, levels of immunohistochemical CD31 and VEGF gene expression as markers of angiogenesis during the muscular phase were investigated. The combined mesenchymal stem cells and atorvastatin added to ivermectin showed the highest significant reduction in adult worms and encysted larvae counts, the most noticeable improvement of the histopathological changes, the most potent anti-inflammatory (lowest level of IL-17) and anti-angiogenic (lowest expression of CD31 and VEGF) activities, and also revealed the highly effective one to relieve the oxidative stress (lowest level of SOD, GSH, and lipid peroxidase enzymes). These observed outcomes indicate that adding mesenchymal stem cells and atorvastatin to ivermectin synergistically potentiates its therapeutic efficacy and provides a promising candidate against trichinellosis.

Indexed as

Trichinella spiralisTrichinellosisAnimalsAtorvastatinIvermectinLarvaMaleMiceVascular Endothelial Growth Factor AAtorvastatinIvermectinVascular Endothelial Growth Factor AAngiogenesisAntioxidantAtorvastatinCD31IvermectinMesenchymal stem cellsTrichinellosis

Identifiers

PMID38105357
PMCPMC10725854
OpenAlexW4389899987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.