ArticleCancer imaging : the official publication of the International Cancer Imaging Society2023
T1 and T2 mapping for identifying malignant lymph nodes in head and neck squamous cell carcinoma.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Multiparametric MRI Assessment of Cervical Lymphadenopathy: Combined Diagnostic Performance of Morphological Features and Apparent Diffusion Coefficient.Healthcare (Basel, Switzerland) · 2026Article
- Clinical Utility of Quantitative MRI Parameters for Differentiation of Renal Tumor Subtypes and Who Grades: A Multiparametric Approach with Internal Cortical Reference.Journal of clinical medicine · 2026Article
- An Interpretable Machine Learning Model With Synthetic MRI-Based Habitat Radiomics for Predicting Lymph Node Metastasis in Oral Cancer.Cancer medicine · 2026Article
- A novel biomarker for identifying HER2-low breast cancer using synthetic MRI.Scientific reports · 2025Article
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- Technical development and In Silico implementation of SyntheticMR in head and neck adaptive radiation therapy: A prospective R-IDEAL stage 0/1 technology development report.Journal of applied clinical medical physics · 2025Article
- Technical Optimization of SyntheticMR for the Head and Neck on a 3T MR-Simulator and 1.5T MR-Linac: A Prospective R-IDEAL Stage 2a Technology Innovation Report.medRxiv : the preprint server for health sciences · 2025Article
- Amide proton transfer-weighted imaging and T1 mapping as diagnostic tools to evaluate high-risk histopathologic phenotypes before surgery in rectal adenocarcinoma and their correlation with Ki-67 expression:a two-center study.Frontiers in oncology · 2025Article
- Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells.Stem cell research & therapy · 2024Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThis study seeks to assess the utility of T1 and T2 mapping in distinguishing metastatic lymph nodes from reactive lymphadenopathy in patients with head and neck squamous cell carcinoma (HNSCC), using diffusion-weighted imaging (DWI) as a comparison.
methodsBetween July 2017 and November 2019, 46 HNSCC patients underwent neck MRI inclusive of T1 and T2 mapping and DWI. Quantitative measurements derived from preoperative T1 and T2 mapping and DWI of metastatic and non-metastatic lymph nodes were compared using independent samples t-test or Mann-Whitney U test. Receiver operating characteristic curves and the DeLong test were employed to determine the most effective diagnostic methodology.
resultsWe examined a total of 122 lymph nodes, 45 (36.9%) of which were metastatic proven by pathology. Mean T2 values for metastatic lymph nodes were significantly lower than those for benign lymph nodes (p < 0.001). Conversely, metastatic lymph nodes exhibited significantly higher apparent diffusion coefficient (ADC) and standard deviation of T1 values (T1
conclusionsThe application of T1 and T2 mapping is feasible in differentiating metastatic from non-metastatic lymph nodes in HNSCC and can improve diagnostic efficacy compared to DWI.
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