Evidence map›Paper›PMID 38104896›Full record

ReviewAdvanced drug delivery reviews2024

Potentials of ionic liquids to overcome physical and biological barriers.

Elfa Beaven, Raj Kumar, Jeong Man An, Hannia Mendoza, Sabuj Chandra Sutradhar, Wonho Choi, Mahesh Narayan, Yong-Kyu Lee, Md Nurunnabi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Design Principles and Applications of Ionic Liquids for Transdermal Drug Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elfa BeavenDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, TX 79902, United States; Biomedical Engineering Program, College of Engineering, University of Texas at El Paso, El Paso, TX 79968, United States.
Raj KumarDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, TX 79902, United States; Biomedical Engineering Program, College of Engineering, University of Texas at El Paso, El Paso, TX 79968, United States.
Jeong Man AnDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea.
Hannia MendozaDepartment of Chemistry and Biochemistry, College of Science, University of Texas at El Paso, El Paso, TX 79968, United States.
Sabuj Chandra Sutradhar4D Convergence Technology Institute, Korea National University of Transportation, Jungpyeong 27909, Republic of Korea.
Wonho Choi4D Convergence Technology Institute, Korea National University of Transportation, Jungpyeong 27909, Republic of Korea.
Mahesh NarayanDepartment of Chemistry and Biochemistry, College of Science, University of Texas at El Paso, El Paso, TX 79968, United States.
Yong-Kyu LeeDepartment of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea; Department of Chemical and Biological Engineering, College of Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea; 4D Convergence Technology Institute, Korea National University of Transportation, Jungpyeong 27909, Republic of Korea. Electronic address: leeyk@ut.ac.kr.
Md NurunnabiDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, TX 79902, United States; Biomedical Engineering Program, College of Engineering, University of Texas at El Paso, El Paso, TX 79968, United States; Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, United States. Electronic address: mnurunnabi@utep.edu.

Funding

Using Common Fund datasets for xenobiotic localizationR03OD032624 · OD · UNIVERSITY OF TEXAS EL PASO · PI NURUNNABI, MD · 2021 to 2021
$304k
NIH HHS R03 OD032624
6 · The paper itself

Abstract

Over the last decades, ionic liquids (IL) have shown great potential in non-invasive delivery starting from synthetic small molecules to biological large molecules. ILs are emerging as a particular class of drug delivery systems due to their unique physiochemical properties, simple surface modification, and functionalization. These features of IL help achieve specific design principles that are essential for a non-invasive drug delivery system. In this review, we have discussed IL and their applications in non-invasive drug delivery systems. We evaluated state-of-the-art development and advances of IL aiming to mitigate the biological and physical barriers to improve transdermal and oral delivery, summarized in this review. We also provided an overview of the various factors determining the systemic transportation of IL-based formulation. Additionally, we have emphasized how the ILs facilitate the transportation of therapeutic molecules by overcoming biological barriers.

Indexed as

Ionic LiquidsAdministration, CutaneousDrug Delivery SystemsHumansIonic LiquidsBiological barrierIonic liquidLocal deliveryNoninvasive deliverySystemic delivery

Identifiers

PMID38104896
PMCPMC10787599

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.