Evidence map›Paper›PMID 38104857›Full record

ArticleContemporary clinical trials2024

Promotion of Successful Weight Management in Overweight and Obese Veterans (POWER-VET): Trial Design and Methods.

Monica C Serra, Heidi K Ortmeyer, Alice S Ryan, POWER-VET Project Team

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04131647 (Promotion of Successful Weight Management in Overweight and Obese Veterans), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 72% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04131647 naactive not recruitingnot on this map

Promotion of Successful Weight Management in Overweight and Obese Veterans

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2021 to 2026Enrolled175ConditionsOverweightArmsWeight Maintenance, Weight Maintenance + Intermittent Fasting
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Monica C SerraDivision of Geriatrics, Gerontology & Palliative Medicine and the Sam & Ann Barshop Institute for Longevity & Aging Studies, Department of Medicine, UT Health San Antonio, San Antonio, TX, United States of America; San Antonio Geriatric Research, Education, and Clinical Center (GRECC), South Texas Veterans Health Care System, San Antonio, TX, United States of America.
Heidi K OrtmeyerDivision of Geriatrics and Palliative Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States of America; Baltimore GRECC, VA Maryland Health Care System, Baltimore, MD, United States of America.
Alice S RyanDivision of Geriatrics and Palliative Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States of America; Baltimore GRECC, VA Maryland Health Care System, Baltimore, MD, United States of America. Electronic address: alice.ryan@va.gov.
POWER-VET Project Team
University of Maryland, Baltimore · USLongevity Biotech (United States) · US

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Promotion of Successful Weight Management in Overweight and Obese VeteransI01CX001965 · VA · BALTIMORE VA MEDICAL CENTER · PI ORTMEYER, HEIDI K, RYAN, ALICE S. · 2020 to 2024
–
Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 RehabilitationI01RX004572 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI KATHLEEN A GRIFFITH, ALICE S. RYAN · 2024 to 2026
–
RR&D Research Career Scientist Award ApplicationIK6RX003977 · VA · BALTIMORE VA MEDICAL CENTER · PI ALICE S. RYAN · 2022 to 2026
–
CSRD VA I01 CX001965NIA NIH HHS P30 AG028747RRD VA I01 RX004572RRD VA IK6 RX003977
6 · The paper itself

Abstract

backgroundAlmost 75% of US adults are overweight or obese. Though intentional weight loss of as little as 3% improves physical functioning and reduces cardiometabolic risk, most adults are unsuccessful at long-term weight maintenance. Our hypothesis is that intermittent fasting (IF: short periods of intense energy restriction) will reduce weight regain. IF may combat obesity due to its effects on nutrient-sensing signaling pathways and circadian rhythm. The objective of this randomized clinical trial is to test the effectiveness of an intensive body weight management program with and without IF.

methodsIn the Promotion of Successful Weight Management in Overweight and Obese Veterans (POWER-VET) trial (NCT04131647), 154 middle-aged and older adults (50-75 years) who are overweight and obese (BMI: 25-40 kg/m DISCUSSION: Determining effective, translatable strategies that minimize weight regain following successful weight loss holds public health relevance. This POWER-VET trial introduces an innovative practice of IF to prevent weight regain after clinically significant weight reduction and could provide evidence-based recommendations to promote this type of intervention in middle aged and older adults.

Indexed as

OverweightVeteransAgedDiet, ReducingHumansMiddle AgedObesityRandomized Controlled Trials as TopicWeight GainWeight LossAgingExerciseIntermittent fastingObesityWeight management

Identifiers

PMID38104857
PMCPMC10922382
OpenAlexW4389805764

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.