Evidence map›Paper›PMID 38104403›Full record

ArticleMedical image analysis2024

Acquisition-invariant brain MRI segmentation with informative uncertainties.

Pedro Borges, Richard Shaw, Thomas Varsavsky, Kerstin Kläser, David Thomas, Ivana Drobnjak, Sebastien Ourselin, M Jorge Cardoso

Abstract read
In one paragraph

Article in Medical image analysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. UltimateSynth: MRI Physics for Pan-Contrast AI.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pedro BorgesDepartment of Medical Physics and Biomedical Engineering, UCL, UK; School of Biomedical Engineering and Imaging Sciences, KCL, UK. Electronic address: p.borges.17@ucl.ac.uk.
Richard ShawDepartment of Medical Physics and Biomedical Engineering, UCL, UK; School of Biomedical Engineering and Imaging Sciences, KCL, UK.
Thomas VarsavskyDepartment of Medical Physics and Biomedical Engineering, UCL, UK; School of Biomedical Engineering and Imaging Sciences, KCL, UK.
Kerstin KläserSchool of Biomedical Engineering and Imaging Sciences, KCL, UK.
David ThomasDementia Research Centre, UCL, UK.
Ivana DrobnjakDepartment of Medical Physics and Biomedical Engineering, UCL, UK.
Sebastien OurselinSchool of Biomedical Engineering and Imaging Sciences, KCL, UK.
M Jorge CardosoSchool of Biomedical Engineering and Imaging Sciences, KCL, UK.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904Wellcome Trust 203148
6 · The paper itself

Abstract

Combining multi-site data can strengthen and uncover trends, but is a task that is marred by the influence of site-specific covariates that can bias the data and, therefore, any downstream analyses. Post-hoc multi-site correction methods exist but have strong assumptions that often do not hold in real-world scenarios. Algorithms should be designed in a way that can account for site-specific effects, such as those that arise from sequence parameter choices, and in instances where generalisation fails, should be able to identify such a failure by means of explicit uncertainty modelling. This body of work showcases such an algorithm that can become robust to the physics of acquisition in the context of segmentation tasks while simultaneously modelling uncertainty. We demonstrate that our method not only generalises to complete holdout datasets, preserving segmentation quality but does so while also accounting for site-specific sequence choices, which also allows it to perform as a harmonisation tool.

Indexed as

Magnetic Resonance ImagingNeuroimagingAlgorithmsBrainHumansImage Processing, Computer-AssistedUncertaintyDeep learningHarmonisationMRI physicsSimulationUncertainty modelling

Identifiers

PMID38104403
PMCPMC7617170

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.