Evidence map›Paper›PMID 38104296›Full record

Trial reportJournal of neural transmission (Vienna, Austria : 1996)2024

Motor cortex transcranial direct current stimulation improves non-motor symptoms in early-onset Parkinson's disease: a pilot study.

Clara Simonetta, Jacopo Bissacco, Matteo Conti, Roberta Bovenzi, Chiara Salimei, Rocco Cerroni, Mariangela Pierantozzi, Alessandro Stefani, Nicola Biagio Mercuri, Tommaso Schirinzi

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neural transmission (Vienna, Austria : 1996), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Fatigue in Parkinson's disease and management with NIBS.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  5. Article
  6. Pain and fatigue in Parkinson's disease: advances in diagnosis and management.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Clara SimonettaUnit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 00133, Rome, Italy.
Jacopo BissaccoUnit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 00133, Rome, Italy.
Matteo ContiUnit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 00133, Rome, Italy.
Roberta BovenziUnit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 00133, Rome, Italy.
Chiara SalimeiDepartment of Clinical Sciences and Translational Medicine, Tor Vergata University of Rome, Rome, Italy.
Rocco CerroniUnit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 00133, Rome, Italy.
Mariangela PierantozziUnit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 00133, Rome, Italy.
Alessandro StefaniUnit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 00133, Rome, Italy.
Nicola Biagio MercuriUnit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 00133, Rome, Italy.
Tommaso SchirinziUnit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 00133, Rome, Italy. t.schirinzi@yahoo.com.ORCID 0000-0002-2517-6278
University of Rome Tor Vergata · IT

Funding

Banca d'Italia Contributi LiberaliFondazione Giovan Battista Baroni Bandi per la ricerca 2021
6 · The paper itself

Abstract

Early-onset Parkinson's Disease (EOPD) demands tailored treatments. The younger age of patients might account for a higher sensitivity to transcranial direct current stimulation (tDCS) based non-invasive neuromodulation, which may raise as an integrative therapy in the field. Accordingly, here we assessed the safety and efficacy of the primary left motor cortex (M1) anodal tDCS in EOPD. Ten idiopathic EOPD patients received tDCS at 2.0 mA per 20 min for 10 days within a crossover, double-blind, sham-controlled pilot study. The outcome was evaluated by measuring changes in MDS-UPDRS part III, Non-Motor Symptoms Scale (NMSS), PD-cognitive rating scale, and PD Quality of Life Questionnaire-39 scores. We showed that anodal but not sham tDCS significantly reduced the NMSS total and "item 2" (sleep/fatigue) scores. Other parameters were not modified. No adverse events occurred. M1 anodal tDCS might thus evoke plasticity changes in cortical-subcortical circuits involved in non-motor functions, supporting the value as a therapeutic option in EOPD.

Indexed as

Motor CortexParkinson DiseaseTranscranial Direct Current StimulationCross-Over StudiesDouble-Blind MethodHumansPilot ProjectsQuality of LifeEarly-onset Parkinson’s diseaseNon-motor symptomstDCS

Identifiers

PMID38104296
OpenAlexW4389857099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.