ArticleACS sensors2023
Microscale, Electrochemical, Aptamer-Based Sensors for Enhanced Small-Molecule Detection at Millisecond Time Scales.
Article in ACS sensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Flexible Multimodal Neural Probe with Integrated Three-Electrode Aptameric Sensing for In Vivo Monitoring of Dopamine Dynamics and Neural Activity.ACS chemical neuroscience · 2026Article
- Thin-Wall Single-Crystal Gold Nanoelectrodes toward Advanced Chemical Probing and Imaging.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Aptamer-Based Scanning Electrochemical Microscopy for Specific and Localized Detection of Analyte Concentration.ACS electrochemistry · 2026Article
- Aptamers-based wearable electrochemical sensors for continuous monitoring of biomarkers in vivo.Microsystems & nanoengineering · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Microscale electrodes offer the advantages of increased mass transport rates, high sensitivity, and rapid measurement capabilities. Fabricating electrochemical aptamer-based (E-AB) sensors on these electrode platforms opens new applications to chemical and biological sensing but has remained challenging due to low signal-to-noise ratios and monolayer instability. In this article, we report the development and characterization of E-AB sensors on a gold microelectrode platform (∼500 nm radius). To overcome the small current response, we modified the electrodes by growing nanostructures via electrodeposition. We interrogated the sensors with two different electroanalytical techniques, square wave voltammetry (SWV) and intermittent pulse voltammetry (IPA), to measure the representative response of an ATP sensor and determine aptamer-target binding and dissociation time scales. We find robust and stable sensor performance with an increased response rate over sensors fabricated on macroscale electrodes. These results demonstrate that sensors developed on this microelectrode platform can be employed for enhanced spatiotemporal resolution measurements in chemical and biological environments.
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Registered trials
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