Evidence map›Paper›PMID 38104122›Full record

ArticleNature communications2023

Soft ferroelectret ultrasound receiver for targeted peripheral neuromodulation.

Tong Li, Zhidong Wei, Fei Jin, Yongjiu Yuan, Weiying Zheng, Lili Qian, Hongbo Wang, Lisha Hua, Juan Ma, Huanhuan Zhang and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

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  16. Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Tong Li *School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Zhidong Wei *School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.ORCID 0000-0001-9210-5528
Fei Jin *School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.ORCID 0000-0002-5670-3915
Yongjiu YuanDepartment of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China.
Weiying ZhengSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Lili QianSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.ORCID 0000-0001-9058-3112
Hongbo WangDepartment of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China.ORCID 0000-0001-7848-2829
Lisha HuaDepartment of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China.
Juan MaSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Huanhuan ZhangDepartment of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China.
Huaduo GuDepartment of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China.
Michael G IrwinDepartment of Anaesthesiology, The University of Hong Kong, Hong Kong, 999077, China.ORCID 0000-0001-5801-274X
Ting WangState Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China. tingwang@seu.edu.cn.ORCID 0000-0002-7518-6298
Steven WangDepartment of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China. steven.wang@cityu.edu.hk.
Zuankai WangDepartment of Mechanical Engineering, The Hong Kong Polytechnic University, Hong Kong, 999077, China. zk.wang@polyu.edu.hk.ORCID 0000-0002-3510-1122
Zhang-Qi FengSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China. fengzhangqi1981@163.com.ORCID 0000-0002-1684-588X
City University of Hong Kong · HKNanjing University of Science and Technology · CNHong Kong Polytechnic University · HKSoutheast University · CNUniversity of Hong Kong · HK

Funding

China Postdoctoral Science Foundation 2023M731696, 2022TQ0158 and 2022M721616National Natural Science Foundation of China (National Science Foundation of China) 82302406, 51773093 and 11204033
6 · The paper itself

Abstract

Bioelectronic medicine is a rapidly growing field where targeted electrical signals can act as an adjunct or alternative to drugs to treat neurological disorders and diseases via stimulating the peripheral nervous system on demand. However, current existing strategies are limited by external battery requirements, and the injury and inflammation caused by the mechanical mismatch between rigid electrodes and soft nerves. Here we report a wireless, leadless, and battery-free ferroelectret implant, termed NeuroRing, that wraps around the target peripheral nerve and demonstrates high mechanical conformability to dynamic motion nerve tissue. As-fabricated NeuroRing can act as an ultrasound receiver that converts ultrasound vibrations into electrostimulation pulses, thus stimulating the targeted peripheral nerve on demand. This capability is demonstrated by the precise modulation of the sacral splanchnic nerve to treat colitis, providing a framework for future bioelectronic medicines that offer an alternative to non-specific pharmacological approaches.

Indexed as

Nerve TissuePeripheral NervesElectrodesPeripheral Nervous SystemProstheses and Implants

Identifiers

PMID38104122
PMCPMC10725454
OpenAlexW4389848376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.