Evidence map›Paper›PMID 38103555›Full record

ReviewMolecular cell2024

NPR1, a key immune regulator for plant survival under biotic and abiotic stresses.

Raul Zavaliev, Xinnian Dong

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
57.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 145 citations in OpenAlex.

  1. Review
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  9. Biocontrol Efficacy and Mechanism of Action ofJournal of fungi (Basel, Switzerland) · 2026
    Article
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Raul ZavalievHoward Hughes Medical Institute, Department of Biology, Duke University, Durham, NC 27708, USA. Electronic address: raul.zavaliev@duke.edu.
Xinnian DongHoward Hughes Medical Institute, Department of Biology, Duke University, Durham, NC 27708, USA. Electronic address: xdong@duke.edu.
Duke University · USHoward Hughes Medical Institute · US

Funding

Salicylic Acid in Immunity and Health: A Small Phytohormone with Big Physiological ImpactsR35GM118036 · NIGMS · DUKE UNIVERSITY · PI Xinnian Dong · 2016 to 2026
$4.0M
NIGMS NIH HHS R35 GM118036
6 · The paper itself

Abstract

Nonexpressor of pathogenesis-related genes 1 (NPR1) was discovered in Arabidopsis as an activator of salicylic acid (SA)-mediated immune responses nearly 30 years ago. How NPR1 confers resistance against a variety of pathogens and stresses has been extensively studied; however, only in recent years have the underlying molecular mechanisms been uncovered, particularly NPR1's role in SA-mediated transcriptional reprogramming, stress protein homeostasis, and cell survival. Structural analyses ultimately defined NPR1 and its paralogs as SA receptors. The SA-bound NPR1 dimer induces transcription by bridging two TGA transcription factor dimers, forming an enhanceosome. Moreover, NPR1 orchestrates its multiple functions through the formation of distinct nuclear and cytoplasmic biomolecular condensates. Furthermore, NPR1 plays a central role in plant health by regulating the crosstalk between SA and other defense and growth hormones. In this review, we focus on these recent advances and discuss how NPR1 can be utilized to engineer resistance against biotic and abiotic stresses.

Indexed as

ArabidopsisArabidopsis ProteinsGene Expression Regulation, PlantSalicylic AcidStress, PhysiologicalTranscription FactorsArabidopsis ProteinsNPR1 protein, ArabidopsisSalicylic AcidTranscription Factorscrop protectiondisease resistanceNPR1plant immunityplant stresssalicylic acidsystemic acquired resistance

Identifiers

PMID38103555
PMCPMC10929286
OpenAlexW4389795848

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.