Evidence map›Paper›PMID 38103545›Full record

ReviewNeuron2024

Lights, fiber, action! A primer on in vivo fiber photometry.

Eleanor H Simpson, Thomas Akam, Tommaso Patriarchi, Marta Blanco-Pozo, Lauren M Burgeno, Ali Mohebi, Stephanie J Cragg, Mark E Walton

Abstract readReview
In one paragraph

Review in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed.

  1. Article
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  5. Striatal cholinergic and dopaminergic driven astrocyte CabioRxiv : the preprint server for biology · 2026
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  11. Fabrication of High-Density Multimodal Neural Probes Based on Heterogeneously Integrated CMOS.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  12. Article
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  17. Visual attention is linked to temporally structured noradrenaline release in the medial prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  18. HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  19. Review
  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eleanor H SimpsonDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA. Electronic address: es534@cumc.columbia.edu.
Thomas AkamDepartment of Experimental Psychology, University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK. Electronic address: thomas.akam@psy.ox.ac.uk.
Tommaso PatriarchiInstitute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland; Neuroscience Center Zürich, University and ETH Zürich, Zürich, Switzerland. Electronic address: patriarchi@pharma.uzh.ch.
Marta Blanco-PozoDepartment of Experimental Psychology, University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.
Lauren M BurgenoDepartment of Experimental Psychology, University of Oxford, Oxford, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Ali MohebiDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Stephanie J CraggDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Mark E WaltonDepartment of Experimental Psychology, University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.

Funding

Timing & Associative LearningR01MH068073 · NIMH · BARNARD COLLEGE · PI BALSAM, PETER D. · 2003 to 2024
$8.0M
Dopaminergic modulation of prefrontal cortex during working memoryK01MH126223 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOHEBI, ALI · 2021 to 2023
$575k
Medical Research Council MR/K013866/1NIMH NIH HHS K01 MH126223NIMH NIH HHS R01 MH068073Parkinson's UK G-1305Wellcome Trust
6 · The paper itself

Abstract

Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo. Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via genetically encoded indicators. This generated new insights into brain functions including movement, memory, and motivation at the level of defined circuits and cell types. Recently, the opportunity for discovery with fiber photometry has exploded with the development of an extensive range of fluorescent sensors for biomolecules including neuromodulators and peptides that were previously inaccessible in vivo. This critical advance, combined with the new availability of affordable "plug-and-play" recording systems, has made monitoring molecules with high spatiotemporal precision during behavior highly accessible. However, while opening exciting new avenues for research, the rapid expansion in fiber photometry applications has occurred without coordination or consensus on best practices. Here, we provide a comprehensive guide to help end-users execute, analyze, and suitably interpret fiber photometry studies.

Indexed as

BrainNeuronsCalciumPhotometryCalciumbiobehavioral techniquesfiber photometrygenetically encoded biosensorsin vivo recording

Identifiers

PMID38103545
PMCPMC10939905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.