ArticleCell host & microbe2024
Plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection.
Article in Cell host & microbe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 110 citations in OpenAlex.
- Biomimetic stress granules replenish lysosomal repair to reinstate macrophage immunometabolic antibacterial programs.Bioactive materials · 2027Article
- Cross-kingdom RNA in plant-microbe interactions: from molecular interactions to next-generation crop protection.Stress biology · 2026Review
- Extracellular vesicles derived from the lactic acid bacterium Enterococcus rotai suppress melanogenesis by modulating the cAMP-MITF pathway.Bioresources and bioprocessing · 2026Article
- Review
- Long noncoding RNAs cross kingdoms to broaden host-pathogen dialogue.Cell research · 2026Article
- Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circulation research · 2026Review
- Integrated omics analyses reveal natamycin disrupts oxidative phosphorylation pathways in Magnaporthe oryzae.BMC plant biology · 2026Article
- Extracellular Vesicles: Key Mediators of Bioactive Molecule Transport in Plant-Microbe Interactions.Molecular plant pathology · 2026Review
- Endophytic entomopathogenic fungi: The next frontier in mycological biocontrol.World journal of microbiology & biotechnology · 2026Review
- Localization and Functional Analysis of CtLTP8, an Extracellular Vesicle Protein That Enhances Resistance toPlants (Basel, Switzerland) · 2026Article
- New molecular pieces in the jigsaw of extracellular vesicle biogenesis.Plant physiology · 2026Article
- Phytophthora targets plant extracellular vesicles to promote infection.Nature microbiology · 2026Article
- Cross-kingdom RNAi: a universal mechanism of inter-organismal communication with many unknowns.Journal of experimental botany · 2026Review
- Nuclear import of malaria RNA rewires splicing in host immune cells.Cell reports · 2026Article
- OsRNS4-mediated cross-kingdom RNA interference is inhibited byScience advances · 2026Article
- Molecular insights into the production of extracellular vesicles by plants.Plant physiology · 2026Article
- CtTLP13 Located in Extracellular Vesicles Enhances the Resistance of Safflower (Carthamus tinctorius) to Botrytis cinerea.Molecular plant pathology · 2026Article
- Foliar-applied double-stranded RNA is mobile, transfers to plant pathogens, and triggers RNAi.Nucleic acids research · 2026Article
- From Nature to Nanomedicine: Engineered Plant-Derived Nanovesicles for Skin Disease.International journal of nanomedicine · 2026Review
- Application of stem cell-derived exosomes in skin wound healing: mechanisms, prospects, and challenges.Frontiers in immunology · 2026Review
5 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
Cross-kingdom small RNA trafficking between hosts and microbes modulates gene expression in the interacting partners during infection. However, whether other RNAs are also transferred is unclear. Here, we discover that host plant Arabidopsis thaliana delivers mRNAs via extracellular vesicles (EVs) into the fungal pathogen Botrytis cinerea. A fluorescent RNA aptamer reporter Broccoli system reveals host mRNAs in EVs and recipient fungal cells. Using translating ribosome affinity purification profiling and polysome analysis, we observe that delivered host mRNAs are translated in fungal cells. Ectopic expression of two transferred host mRNAs in B. cinerea shows that their proteins are detrimental to infection. Arabidopsis knockout mutants of the genes corresponding to these transferred mRNAs are more susceptible. Thus, plants have a strategy to reduce infection by transporting mRNAs into fungal cells. mRNAs transferred from plants to pathogenic fungi are translated to compromise infection, providing knowledge that helps combat crop diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.