Evidence map›Paper›PMID 38102963›Full record

ArticlePediatric blood & cancer2024

Challenging our understanding of B-cell lymphomagenesis and risk: Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion.

Lucy Hare, Jamie Trotman, Patrick Tarpey, Elizabeth Hook, G A Amos Burke, Genomics England Research Consortium

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lucy HareDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0001-8159-6165
Jamie TrotmanEast-Genomics Laboratory Hub (GLH) Genetics Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID https://orcid.org/0000-0002-6246-4121
Patrick TarpeyEast-Genomics Laboratory Hub (GLH) Genetics Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Elizabeth HookDepartment of Pathology, University of Cambridge, Cambridge, UK.
G A Amos BurkeDepartment of Paediatric Haematology, Oncology and Palliative Care, Addenbrooke's Hospital, Cambridge, UK.
Genomics England Research Consortium
Cambridge University Hospitals NHS Foundation Trust · GBUniversity of Cambridge · GBAddenbrooke's Hospital · GB

Funding

Cancer Research UK Cambridge Centre clinical research fellowship C9685/A25117Wellcome Trust
6 · The paper itself

Abstract

We report a unique case of high-grade B-cell lymphoma, not otherwise specified in a 5-year-old child. Whole-genome sequencing revealed a DDX3X::MLLT10 fusion, usually seen in T-cell acute lymphoblastic leukaemia (ALL). This suggests the novel idea that MLLT10 fusions are capable of driving B-cell malignancies. An IGH deletion usually only seen in adults was also found. These unique genetic findings provide novel insights into B-cell lymphomagenesis. The child remains in remission 7 year post chemotherapy, which demonstrates that novel complex molecular findings do not always denote high-risk disease.

Indexed as

Lymphoma, B-CellPrecursor T-Cell Lymphoblastic Leukemia-LymphomaAdultB-LymphocytesChildChild, PreschoolDEAD-box RNA HelicasesHumansTranscription FactorsDDX3X protein, humanDEAD-box RNA HelicasesMLLT10 protein, humanTranscription FactorsHGBLlymphomaMLLT10NOS

Identifiers

PMID38102963
PMCPMC11497301
OpenAlexW4389828370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.