Evidence map›Paper›PMID 38102659›Full record

ArticleCell & bioscience2023

Neural EGFL-like 1, a craniosynostosis-related osteochondrogenic molecule, strikingly associates with neurodevelopmental pathologies.

Chenshuang Li, Zhong Zheng, Pin Ha, Wenlu Jiang, Chia Soo, Kang Ting

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. NELL-1: role and mechanisms in disease pathogenesis and development.Frontiers in cell and developmental biology · 2026
    Review
  2. [Advances in Molecular Regulatory Mechanisms of Jaw Repair and Reconstruction].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chenshuang Li *Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zhong Zheng *David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Pin HaDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Wenlu JiangSchool of Dentistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Chia SooDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. bsoo@g.ucla.edu.
Kang TingAmerican Dental Association Forsyth Institute, 245 First Street, Cambridge, MA, 02142, USA. erickangting@gmail.com.
University of California, Los Angeles · USAmerican Dental Association · USUniversity of Pennsylvania · US

Funding

Dual roles of Nell-1 in craniofacial bones and brain through interaction with Cntnap4R01DE029353 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOO, CHIA, ZHANG, XINLI · 2020 to 2024
$2.5M
NELL-1's functional role in cartilage regenerationR01AR068835 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, SOO, CHIA · 2015 to 2019
$2.2M
NELL-1 Systemic Therapy for OsteoporosisR01AR066782 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, TING, KANG · 2014 to 2018
$2.0M
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and developmentR03DE030400 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI LI, CHENSHUANG · 2023 to 2023
$325k
NIAMS NIH HHS R01 AR066782NIAMS NIH HHS R01AR066782NIAMS NIH HHS R01 AR068835NIAMS NIH HHS R01AR068835NIDCR NIH HHS R01 DE029353NIDCR NIH HHS R03 DE030400NIDCR NIH HHS R03DE030400
6 · The paper itself

Abstract

Various craniofacial syndromes cause skeletal malformations and are accompanied by neurological abnormalities at different levels, leading to tremendous biomedical, financial, social, and psychological burdens. Accumulating evidence highlights the importance of identifying and characterizing the genetic basis that synchronously modulates musculoskeletal and neurobehavioral development and function. Particularly, previous studies from different groups have suggested that neural EGFL-like-1 (Nell-1), a well-established osteochondrogenic inducer whose biopotency was initially identified in the craniofacial tissues, may also play a vital role in the central nervous system, particularly regarding neurological disorder pathologies. To provide first-hand behavior evidence if Nell-1 also has a role in central nervous system abnormalities, we compared the Nell-1-haploinsufficient (Nell-1

Indexed as

Autism spectrum disorderBone-brain-crosstalkNeural EGFL-like 1Neurodevelopmental

Identifiers

PMID38102659
PMCPMC10725010
OpenAlexW4389783714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.