Evidence map›Paper›PMID 38102636›Full record

SynthesisBMC endocrine disorders2023

Soluble receptor for advanced glycation end products (sRAGE) is associated with obesity rates: a systematic review and meta-analysis of cross-sectional study.

Nahla A Tayyib, Pushpamala Ramaiah, Shadia Hamoud Alshahrani, Ria Margiana, Sami G Almalki, A K Kareem, Rahman S Zabibah, Abdullah M Shbeer, Saad Hayif Jasim Ali, Yasser Fakri Mustafa

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC endocrine disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 3 countries.

Nahla A TayyibVice Deanship, Postgraduate Research and Scientific Studies, Faculty of Nursing, Umm Al-Qura University, Makkah, Saudi Arabia.
Pushpamala RamaiahFaculty of Nursing, Umm al- Qura University, Makkah, Saudi Arabia. ramaiahpushpamala@gmail.com.
Shadia Hamoud AlshahraniMedical Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia.
Ria MargianaDepartment of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Sami G AlmalkiDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah, 11952, Saudi Arabia.
A K KareemBiomedical Engineering Department, Al-Mustaqbal University College, Babylon, Iraq.
Rahman S ZabibahMedical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq.
Abdullah M ShbeerDepartment of Surgery, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia.
Saad Hayif Jasim AliDepartment of medical laboratory, College of Health and Medical Technololgy, Al-Ayen University, Thi-Qar, Iraq.
Yasser Fakri MustafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
Umm al-Qura University · SAIraqi University · IQJazan University · SAKing Khalid University · SAMajmaah University · SAThi Qar University · IQUniversitas Dr. Soetomo · IDUniversity of Mosul · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies have highlighted the possible positive effects of soluble receptor for advanced glycation end products (sRAGE) against obesity. However, due to their inconsistent results, this systematic review and meta-analysis aimed to quantitatively evaluate and critically review the results of studies evaluating the relationship between sRAGE with obesity among adult population.

methodsIn the systematic search, the eligibility criteria were as follows: studies conducted with a cross-sectional design, included apparently healthy adults, adults with obesity, or obesity-related disorders, aged over 18 years, and evaluated the association between general or central obesity indices with sRAGE.

resultsOur systematic search in electronic databases, including PubMed, Scopus, and Embase up to 26 October, 2023 yielded a total of 21,612 articles. After removing duplicates, screening the titles and abstracts, and reading the full texts, 13 manuscripts were included in the final meta-analysis. According to our results, those at the highest category of circulating sRAGE concentration with median values of 934.92 pg/ml of sRAGE, had 1.9 kg/m

conclusionAccording to our results, higher circulating sRAGE concentrations was associated with lower BMI and WC among apparently healthy adults. Further randomized clinical trials are warranted for possible identification of causal associations.

Indexed as

Glycation End Products, AdvancedObesityAdultBody Mass IndexCross-Sectional StudiesHumansMiddle AgedReceptor for Advanced Glycation End ProductsWeight LossGlycation End Products, AdvancedReceptor for Advanced Glycation End ProductsAdultMeta-analysisObesitysRAGESystematic review

Identifiers

PMID38102636
PMCPMC10722718
OpenAlexW4389790754

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.