Evidence map›Paper›PMID 38102601›Full record

ArticleBMC veterinary research2023

Effect of glutamine on the systemic innate immune response in broiler chickens challenged with Salmonella pullorum.

Qiu Jue Wu, Long Long Zhu, Rong Kai Zhang, Zhong Ying Xing, Cong Wang, Jia Hui Liao, Nai Zhi Hu, Bin Yao Cheng, Yan Ma, Yu Qin Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Qiu Jue Wu *College of Animal Science and Technology, Henan University of Science and Technology, Henan, 471003, China. wuqiujue@163.com.
Long Long Zhu *College of Animal Science and Technology, Henan University of Science and Technology, Henan, 471003, China.
Rong Kai Zhang *College of Animal Science and Technology, Henan University of Science and Technology, Henan, 471003, China.
Zhong Ying Xing *College of Animal Science and Technology, Henan University of Science and Technology, Henan, 471003, China.
Cong Wang *College of Animal Science and Technology, Henan University of Science and Technology, Henan, 471003, China.
Jia Hui Liao *College of Animal Science and Technology, Henan University of Science and Technology, Henan, 471003, China.
Nai Zhi Hu *College of Animal Science and Technology, Henan University of Science and Technology, Henan, 471003, China.
Bin Yao Cheng *College of Animal Science and Technology, Henan University of Science and Technology, Henan, 471003, China.
Yan Ma *College of Animal Science and Technology, Henan University of Science and Technology, Henan, 471003, China.
Yu Qin Wang *College of Animal Science and Technology, Henan University of Science and Technology, Henan, 471003, China.
Henan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study was to evaluate the effects of glutamine on the growth performance and systemic innate immune response in broiler chickens challenged with Salmonella pullorum. A total of 600 one-day-old Arbor Acres broiler chickens were assigned randomly to 6 dietary treatments with 10 replicates for a 21-day feeding experiment. The experimental treatments were as follows: the control treatment (birds fed the basal diet), the Gln1 treatment, and the Gln 2 treatment (birds fed the basal diet supplemented with 0.5%, and 1.0% Glutamine, respectively). At 3 d of age, half of the birds from each treatment were challenged oral gavage with 2.0 × 10

resultsThe results showed that S. pullorum infection had adverse effects on the average daily feed intake, average daily gain, and feed conversion ratio of broiler chickens compared with those of the CON treatment on d 7, decreased the spleen and bursa of fabricius relative weights (except on d 21), serum immunoglobulin A (IgA),immunoglobulin G (IgG), and immunoglobulin M (IgM) concentrations, and spleen melanoma differentiation-associated gene 5 (MDA5) and laboratory of genetics and physiology gene 2 (LGP2) mRNA expression levels, and increased the mRNA expression levels of spleen Nodinitib-1 (NOD1), Toll-like receptors 2,4 (TLR2, TLR4), DNA-dependent activator of IFN-regulatory factors (DAI), mitochondrial antiviral-signaling protein (MAVS), P50, P65, and RelB on d 4, 7, 14, and 21. Supplementation with Gln improved the relative weights of the spleen and bursa of Fabricius (except on d 21), increased the serum IgA, IgG, and IgM concentrations and the mRNA expression levels of spleen MDA5 and LGP2, and decreased the mRNA expression levels of spleen NOD1, TLR2, TLR4, DAI, MAVS, P50, P65, and RelB of S. pullorum-challenged broiler chickens.

conclusionThese results indicate that Gln might stimulate the systemic innate immune responses of the spleen in broiler chickens challenged with S. pullorum.

Indexed as

ChickensToll-Like Receptor 2Animal FeedAnimalsDietDietary SupplementsGlutamineImmunity, InnateImmunoglobulin AImmunoglobulin GImmunoglobulin MRNA, MessengerSalmonellaToll-Like Receptor 4GlutamineImmunoglobulin AImmunoglobulin GImmunoglobulin MRNA, MessengerToll-Like Receptor 2Toll-Like Receptor 4Broiler chickensGlutamineInnate immune responseSalmonella pullorumSpleen

Identifiers

PMID38102601
PMCPMC10724901
OpenAlexW4389828203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.