Evidence map›Paper›PMID 38102598›Full record

ArticleBMC neurology2023

Early antithrombotic therapy in patients with postinterventional cerebral hyperdensity reduces early neurological deterioration after mechanical thrombectomy.

Yunhe Luo, Min Chu, Daosheng Wang, Xin Gu, Delong Wang, Jin Zheng, Jing Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yunhe Luo *Department of Neurology, Minhang Hospital, Fudan University, Shanghai, 201100, China.
Min Chu *Department of Neurology, Minhang Hospital, Fudan University, Shanghai, 201100, China.
Daosheng Wang *Department of Neurosurgery, Minhang Hospital, Fudan University, Shanghai, China.
Xin GuDepartment of Neurology, Minhang Hospital, Fudan University, Shanghai, 201100, China.
Delong WangDepartment of Neurology, Minhang Hospital, Fudan University, Shanghai, 201100, China. wdl900129@126.com.
Jin ZhengDepartment of Neurology, Minhang Hospital, Fudan University, Shanghai, 201100, China. zhengjin22163@fudan.edu.cn.
Jing ZhaoDepartment of Neurology, Minhang Hospital, Fudan University, Shanghai, 201100, China. zhao_jing@fudan.edu.cn.
Fudan University · CN

Funding

National Natural Science Foundation of China 82173646
6 · The paper itself

Abstract

backgroundInitiation of early antithrombotic therapy after acute ischemic stroke (AIS) is crucial. We aimed to investigate whether early antithrombotic therapy influences early neurological deterioration (END) in AIS patients with postinterventional cerebral hyperdensity (PCHD) immediately after mechanical thrombectomy (MT).

methodsWe retrospectively analyzed 108 consecutive anterior circulation AIS patients with PCHD immediately after MT. All patients were divided into END group and non-END group and END was defined as an increase of four points or more on the postinterventional National Institutes of Health Stroke Scale (NIHSS) score within the first 72 h after MT. Early antithrombotic therapy was defined as patients with PCHD who received antithrombotic therapy within 24 h after MT. Statistical analyses were performed to evaluate the association between early antithrombotic therapy and the risk of END.

resultsAmong 108 patients, 27 (25%) patients developed END. Multivariate regression analysis revealed that early use of antithrombotic therapy (OR = 0.229, 95%CI = 0.083-0.626, P = 0.004) was an independent protector of END and postinterventional low density shadow exceeding 1/3 of the vascular territory (OR = 4.000, 95%CI = 1.157-13.834, P = 0.029) was an independent risk factor for END.

conclusionAntithrombotic therapy within 24 h after MT maybe associated with the reduced risk of END in anterior circulation AIS patients with PCHD.

Indexed as

Brain IschemiaIschemic StrokeStrokeFibrinolytic AgentsHumansRetrospective StudiesThrombectomyTreatment OutcomeFibrinolytic AgentsAcute ischemic StrokeAntithrombotic therapyEarly neurological deteriorationMechanical thrombectomyPostinterventional cerebral hyperdensity

Identifiers

PMID38102598
PMCPMC10722751
OpenAlexW4389786832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.