Evidence map›Paper›PMID 38102370›Full record

SynthesisObesity surgery2024

Improvement of Triglyceride-Glucose Index Following Bariatric Surgery: a Systematic Review and Meta-analysis.

Tannaz Jamialahamdi, Kishore M Gadde, Ninh T Nguyen, Matthew Kroh, Vasily N Sukhorukov, Wael Almahmeed, Khalid Al-Rasadi, Amirhossein Sahebkar

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Obesity surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Tannaz JamialahamdiMedical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Kishore M GaddeDepartment of Surgery, University of California Irvine Medical Center, Orange, CA, USA.
Ninh T NguyenDepartment of Surgery, University of California Irvine Medical Center, Orange, CA, USA.
Matthew KrohDigestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Vasily N SukhorukovInstitute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow, 125315, Russia.
Wael AlmahmeedHeart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Khalid Al-RasadiMedical Research Centre, Sultan Qaboos University, Muscat, Oman.
Amirhossein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.ORCID 0000-0002-8656-1444
Mashhad University of Medical Sciences · IRUniversity of California, Irvine Medical Center · USCleveland Clinic · USResearch Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RUSultan Qaboos University · OM

Funding

Russian Science Foundation 236510014
6 · The paper itself

Abstract

backgroundBariatric surgery is an effective intervention for the management of severe obesity and its associated comorbidities, including metabolic abnormalities. This meta-analysis aimed to evaluate the impact of bariatric surgery on the triglyceride-glucose (TyG) index, a novel marker of insulin resistance and metabolic syndrome.

methodsA systematic search was conducted in Embase, PubMed, Web of Science, and Scopus. The meta-analysis was performed using Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was determined by a random-effects meta-analysis and the leave-one-out approach.

resultsA total of 9 trials including 1620 individuals confirmed a significant reduction in TyG following bariatric surgery (weighted mean difference (WMD) - 0.770, 95% CI - 1.006, - 0.534, p < 0.001). In a sub-analysis according to the type of bariatric surgery there was a significant reduction in TyG index for Roux-en-Y gastric bypass (WMD - 0.775, 95% CI - 1.000, - 0.550, p < 0.001), and sleeve gastrectomy (WMD - 0.920, 95% CI - 1.368, - 0.473, p < 0.001). In a sub-analysis according to the follow-up duration there was similarly a significant reduction in TyG index for both < 12 months (WMD - 1.645, 95% CI - 2.123, - 1.167, p < 0.001), and ≥ 12 months follow-up (WMD - 0.954, 95% CI - 1.606, - 0.303, p < 0.001).

conclusionThe results of this meta-analysis demonstrated a significant reduction in the TyG index following bariatric surgery, indicating improved insulin sensitivity and metabolic health. These findings highlight the potential of bariatric surgery as a valuable therapeutic option for individuals with obesity and its metabolic consequences.

Indexed as

Bariatric SurgeryGastric BypassObesity, MorbidGastrectomyGlucoseHumansObesityGlucoseGastric bypassInsulin resistanceMetabolic surgeryObesitySleeve gastrectomyTriglyceride–glucose index

Identifiers

PMID38102370
OpenAlexW4389804900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.