Evidence map›Paper›PMID 38102234›Full record

ArticleScientific reports2023

Early life stress in women with autoimmune thyroid disorders.

Alessia Corso, Hermann Engel, Fabienne Müller, Serena Fiacco, Laura Mernone, Elena Gardini, Ulrike Ehlert, Susanne Fischer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Methods for Modeling Early Life Stress in Rodents.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alessia CorsoInstitute of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Binzmuehlestrasse 14, Box 26, 8050, Zurich, Switzerland.
Hermann EngelThyroid Center Zurich, Zurich, Switzerland.
Fabienne MüllerInstitute of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Binzmuehlestrasse 14, Box 26, 8050, Zurich, Switzerland.
Serena FiaccoInstitute of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Binzmuehlestrasse 14, Box 26, 8050, Zurich, Switzerland.
Laura MernoneInstitute of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Binzmuehlestrasse 14, Box 26, 8050, Zurich, Switzerland.
Elena GardiniInstitute of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Binzmuehlestrasse 14, Box 26, 8050, Zurich, Switzerland.
Ulrike EhlertInstitute of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Binzmuehlestrasse 14, Box 26, 8050, Zurich, Switzerland.
Susanne FischerInstitute of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Binzmuehlestrasse 14, Box 26, 8050, Zurich, Switzerland. s.fischer@psychologie.uzh.ch.
University of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune thyroid disorders (AITD) represent the most frequent of all autoimmune disorders. Their aetiopathogenesis is incompletely understood, but most likely multifactorial. Early life stress can have long-lasting effects on the immune system. The aim of the present study was to investigate, for the first time, whether patients with AITD are more frequently affected by early life stress. A total of N = 208 women were recruited into a case-control study. Of these, n = 78 (median age: 53, interquartile range: 15) were patients recruited from a thyroid outpatient clinic with confirmed Hashimoto's thyroiditis, Graves' disease, or AITD not otherwise specified. The remaining n = 130 age- and BMI-matched women (median age: 53, interquartile range: 12) were recruited from the general population. Early life stress was measured with the Childhood Trauma Questionnaire. Patients with AITD did not differ from controls regarding sexual abuse, physical abuse, and physical neglect. However, a greater number of patients reported emotional neglect (29.7% vs. 19.5%) and emotional abuse (41.3% vs. 32%). This study provides initial evidence for emotional neglect and abuse as potential risk factors for the development of AITD. Prospective confirmation of these findings could pave the way for the development of interventions to prevent AITD in predisposed individuals.

Indexed as

Adverse Childhood ExperiencesAutoimmune DiseasesGraves DiseaseHashimoto DiseaseThyroiditis, AutoimmuneCase-Control StudiesChildFemaleHumansMiddle AgedProspective Studies

Identifiers

PMID38102234
PMCPMC10724129
OpenAlexW4389780970

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.